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Primary undifferentiated sarcoma of the liver is a rare tumor with survival reliant on total excision of the tumor. The authors report such a tumor, initially nonresectable, in a 7‐year‐old girl whose tumor was successfully excised following treatment with cisplatin and Adriamycin (doxorubicin). The light and electron microscopic details of this patienťs tumor are presented.

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Within the past 24 months, we have performed prenatal diagnostic studies in 4 pregnancies known to be at risk for well-described genetic syndrome involving renal abnormalities, ie, Meckel syndrome, Roberts syndrome, and bilateral renal agenesis. The diagnostic techniques utilized were ultrasonographic scanning (B-mode and grey scale), biochemical assays, and radiographic evaluation. The ultrasound finding common to the 3 affected cases was extreme oligohydramnios, which we considered indirect evidence that renal anomalies were present. The ultrasound scans of the fetuses affected with Meckel and Roberts syndrome demonstrated anechoic cystic spaces in the abdomen, representing the enlarged dysplastic cystic kidneys. An encephalocele was well demonstrated by B-mode scan in the fetus with Meckel syndrome. The absence of normal limbs in the Roberts syndrome was evident on serial grey scale scans of the fetus. Biochemical and radiographic studies provided results consistent with the suspected diagnoses. The importance of providing genetic counseling and prenatal diagnosis to families at risk is emphasized.

Intrarenal reflux found during voiding cystourethrography in children has been suggested to be a significant factor in the production of renal damage. To investigate its incidence and effect on renal growth the records and roentgenograms of 150 children with known vesicoureteral reflux were reviewed. Of these children 15 had evidence of intrarenal reflux. Their IVPs were studied for signs of renal parenchymal damage at the time of the initial voiding cystogram as well as up to 4 years later. Evidence of renal damage was seen in 4 of the 15 patients with intrarenal reflux. These same 4 children had gross vesicoureteral reflux.