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Background Surgery is the best way to cure the retroperitoneal leiomyosarcoma (RLMS), and there is currently no prediction model on RLMS after surgical resection. The objective of this study was to develop a nomogram to predict the overall survival (OS) of patients with RLMS after surgical resection. Methods Patients who underwent surgical resection from September 2010 to December 2020 were included. The nomogram was constructed based on the COX regression model, and the discrimination was assessed using the concordance index. The predicted OS and actual OS were evaluated with the assistance of calibration plots. Results 118 patients were included. The median OS for all patients was 47.8 (95% confidence interval (CI), 35.9–59.7) months. Most tumor were completely resected (n = 106, 89.8%). The proportions of French National Federation of Comprehensive Cancer Centres (FNCLCC) classification were equal as grade 1, grade 2, and grade 3 (31.4%, 30.5%, and 38.1%, respectively). The tumor diameter of 73.7% (n = 85) patients was greater than 5 cm, the lesions of 23.7% (n = 28) were multifocal, and 55.1% (n = 65) patients had more than one organ resected. The OS nomogram was constructed based on the number of resected organs, tumor diameter, FNCLCC grade, and multifocal lesions. The concordance index of the nomogram was 0.779 (95% CI, 0.659–0.898), the predicted OS and actual OS were in good fitness in calibration curves. Conclusion The nomogram prediction model established in this study is helpful for postoperative consultation and the selection of patients for clinical trial enrollment.