The treatment of alkoxymethyl-substituted hydrosilanes with palladium on charcoal gave rise to the corresponding alkyl silyl ethers by the migration of the silicon-bound hydrogen atom to the -carbon atom and of the alkoxy group to the silicon center. Kinetic investigations revealed that two parallel reactions are involved in the rearrangement: an intramolecular reaction, following pseudo-first-order kinetics and showing an inverse kinetic deuterium isotope effect, is dominant in the initial phase of the transformation, and an intermolecular reaction becomes important in the later course of the transformation. The dominant reaction in the first phase of the transformation has to be classified as a dyotropic arrangement of type I, due to the intramolecular course and the reaction order, and it represents the first catalyzed example of a rearrangement of this type.

Organic chemistryOrganic chemistry Z 0200Applications of Parallel Synthesis to Lead Optimization -[13 refs.]. -(ALTORFER, M.; ERMERT, P.; FAESSLER, J.; FAROOQ, S.; HILLESHEIM, E.; JEANGUENAT, A.; KLUMPP, K.; MAIENFISCH, P.; MARTIN, J. A.; MERRETT, J. H.; et al.; Chimia 57 (2003) 5, 262-269; Polyphor AG, CH-4123 Allschwil, Switz.; Eng.) -Lindner 04-247

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ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.