The research field entitled structural DNA nanotechnology emerged in the beginning of the 1980s as the first immobile synthetic nucleic acid junctions were postulated and demonstrated. Since then, the field has taken huge leaps toward advanced applications, especially during the past decade. This Progress Report summarizes how the controllable, custom, and accurate nanostructures have recently evolved together with powerful design and simulation software. Simultaneously they have provided a significant expansion of the shape space of the nanostructures. Today, researchers can select the most suitable fabrication methods, and design paradigms and software from a variety of options when creating unique DNA nanoobjects and shapes for a plethora of implementations in materials science, optics, plasmonics, molecular patterning, and nanomedicine.

Today, DNA nanotechnology enables effortless production of user‐defined complex structures with nanometer‐scale precision using DNA as a construction material. These customized objects can find a cornucopia of intriguing uses ranging from materials science to nanophotonics and smart therapeutics. In article number https://doi.org/10.1002/adma.201703721, Mauri A. Kostiainen, Veikko Linko, and co‐workers summarize the rapid progress in the field, including the expansion of the shape space, development of computer‐aided design paradigms, and recent compelling applications.