This paper adopts the method of the random matrix to conduct an in-depth study and analysis of the management of macroeconomic multivariate statistics and regionalization, and to design its management strategy based on a random matrix. A combination of theoretical and applied research, combined with the experience of other cities, is used to study regional economic management using literature analysis, comparative analysis, and deductive induction by summarizing the results achieved in community management, studying its experience, exploring the significance of community management in ETDZs for social development, analyzing the current obstacles and contradictions affecting community management in Suqian ETDZ, and proposing relevant countermeasures for the problems arising therein to enrich the relevant theories and thus promote the level of community management in ETDZs to a higher level. Macroeconomic uncertainty refers to the changes that cannot be accurately observed, analyzed, and foreseen, i.e., the deviation of the expected value of the economy from the actual value. Not all macroeconomic fluctuations belong to the category of macroeconomic uncertainty, only unpredictable economic fluctuations are uncertain. It can be seen from the above that there is a corresponding relationship between the financial income correlation matrix and the random correlation matrix, and both are affected by the same random factors. The importance of uncertainty for macroeconomic policy making is undeniable, and its quantification is a key step. In this paper, we propose an econometric model to eliminate expectations and compare the advantages and disadvantages of different measurement models; we measure a system of fourteen macroeconomic indicators to reflect macroeconomic uncertainty and provide quantitative measurement results for the correct understanding of macroeconomic uncertainty and economic policy making. Factor analysis is used to analyze these six comprehensive aspects to obtain the six-dimensional comprehensive scores of each province and city, and the scores are normalized and visualized. Based on a certain understanding of the economic equilibrium structure of each province and city in China, and a certain control of the overall development of each region itself at this stage, the future economic development trend is studied.