The use of non-invasive morphokinetics is unlikely to discriminate aneuploid from euploid embryos. Further, it does not approach the accuracy of preimplantation genetic screening with array comparative genomic hybridization.

The marked increase in STL heterogeneity as men age is consistent with a role for ALT during spermatogenesis. No data have yet reported the effect of age on STL heterogeneity. Based on these results, future studies should expand this modest sample size to search for molecular evidence of ALT in human testes during spermatogenesis.

During cervical carcinogenesis, the usual relationship between estrogen and ezrin induction is abridged. This is consistent with the effects of human papilloma virus viral proteins such as E6 and E7 that upregulate SIX1, a protein that induces ezrin. Cervical carcinogenesis is progressive but arrests at the preinvasive stage for varying lengths of time. These studies suggest that changes in ezrin may be associated with the development of the invasive phenotype and penetration of the basement membrane. They also raise the possibility that inhibiting ezrin expression could be a target for the prevention of invasive CXCA.

primary objective was met, with a cumulative spontaneous abortion rate of 7.4% with upper bound of the 95% confidence interval (CI; 4.4%, 11.5%) below the predefined threshold of 15.0% set based upon the observed 10.0% rate (CI 7.6%, 12.8%) in the pivotal trial (Stadtmauer 2013). Clinical pregnancy rates were 43.2% at 10 weeks post OR.CONCLUSIONS: This trial established a safety bridge between PVR produced via enhanced manufacturing processes and the legacy PVR based upon a rate of spontaneous abortion comparable to that observed in the pivotal phase 3 trial. Weekly administration of the PVR was well-tolerated with good pregnancy outcomes associated with its use in conjunction with HP-hMG stimulation. Based upon demonstrated safety and efficacy coupled with more convenient dosing than existing therapeutics, PVR offers an important option for luteal phase supplementation.

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