Multidrug resistant (MDR) enteropathogenic bacteria are a growing problem within the clinical environment due to their acquired tolerance to a wide range of antibiotics, thus causing severe illnesses and a tremendous economic impact in the healthcare sector. Due to its difficult treatment, knowledge and understanding of the molecular mechanisms that confer this resistance are needed. The aim of the present review is to describe the mechanisms of antibiotic resistance from a genomic perspective observed in bacteria, including naturally acquired resistance. The present review also discusses common pharmacological and alternative treatments used in cases of infection caused by MDR bacteria, thus covering necessary information for the development of novel antimicrobials and adjuvant molecules inhibiting bacterial proliferation. Contents1. Introduction 2. Multidrug resistant enteropathogenic bacteria 3. Molecular mechanisms of multidrug resistance 4. Molecular mechanisms of multidrug resistance generation 5. Drugs and bacterial response 6. Mechanisms of antibiotics 7. Mechanisms of drug resistance 8. Treatment against multidrug-resistant bacteria 9. Conclusions