A new and efficient domino reaction of 3-chlorochromones with electron-rich aminoheterocycles was developed which allows for a convenient synthesis of a variety of pyrazolo[3,4-b]pyridines, pyrrolo[2,3-b]pyridines, pyrido[2,3-d]pyrimidines and benzofuro[3,2-b]pyridines. The products exhibit strong fluorescence. In addition, they exhibit significant ecto-5'-nucleotidase inhibition properties and cytotoxic behavior.

Two concise and efficient approaches were developed for the synthesis of α- and δ-carboline derivatives. The success of the synthesis relies on site-selective Suzuki-Miyaura reactions of 1-chloro-2-bromopyridine or 2,3-dibromopyridine with 2-bromophenylboronic acid and subsequent cyclization with amines which proceeds by twofold Pd-catalyzed C-N coupling reactions.

A series of new heteroannulated pyrido[2,3‐c]coumarins have been prepared by the domino reactions of chromone‐3‐carboxylic acid derivatives with electron‐rich binucleophilic aminoheterocycles. The products contain the core structures of coumarin, pyridine, and an annulated five‐membered heterocyclic system, namely pyrazole, pyrrole, or isoazole. The fluorescence of the products was investigated. The products inhibit ecto‐5′‐nucleotidase (e5′NT) enzymatic activity.

The Buchwald–Hartwig amination allows an efficient and convenient synthesis of biologically and pharmaceutically important acridones by formation of a six-membered ring. With the described method, a number of derivatives have been synthesized in up to 95% yield by using a variety of anilines as well as benzylic and aliphatic amines.

A variety of thienoquinolones were synthesized from readily accessible thiophene derivatives by regioselective acylations and subsequent two-fold Buchwald-Hartwig-amination. This cyclization allows a convenient synthesis of biologically [a]