The extent to which neural networks underlying emotional behavior in infancy serve as precursors of later behavioral and emotional problems is unclear. Even less is known about caregiving influences on these early brain-behavior relationships. To study brain-emotional behavior relationships in infants, we examined resting-state functional network metrics and infant emotional behavior in the context of early maternal caregiving. We assessed 46 3-month-old infants and their mothers from a community sample. Infants underwent functional MRI during sleep. Resting-state data were processed using graph theory techniques to examine specific nodal metrics as indicators of network functionality. Infant positive and negative emotional behaviors, and positive, negative and mental-state talk (MST) indices of maternal caregiving were coded independently from filmed interactions. Regression analyses tested associations among nodal metrics and infant emotionality, and the moderating effects of maternal behavior on these relationships. All results were FDR corrected at alpha = 0.05. While relationships between infant emotional behavior or maternal caregiving, and nodal metrics were weak, higher levels of maternal MST strengthened associations between infant positive emotionality and nodal metrics within prefrontal (p < 0.0001), and occipital (p < 0.0001) cortices more generally. Positive and negative aspects of maternal caregiving had little effect. Our findings suggest that maternal MST may play an important role in strengthening links between emotion regulation neural circuitry and early infant positive behavior. They also provide objective neural markers that could inform and monitor caregiving-based interventions designed to improve the health and well-being of vulnerable infants at-risk for behavioral and emotional problems.

The present study takes a transactional approach to extend understanding of temporal relations between parenting behaviors and infant response to the face‐to‐face still‐face, a widely used method assessing infants’ affective and behavioral response to a violation of social expectations. A low‐income, urban sample of 180 mothers and infants participated when infants were 4 and 6 months old. Directional relations between infants’ still‐face response (i.e., change in affect and gaze from interaction to still face) and three parenting dimensions were examined using cross‐lagged structural equation models. Infant still‐face response predicted later parenting behavior, while the reverse association was not significant. Specifically, infants with a greater reduction in positive affect from interaction to still face had parents with more positive parenting and less negative parenting behaviors 2 months later, controlling for prior parenting and concurrent infant behavior. Furthermore, infants who increased gaze to mother from interaction to still face had mothers who used more mental state talk 2 months later. Findings underscore the importance of examining transactional relations between infant and parent behaviors, and in particular highlight the influence of infants on parents. Acknowledging these infant‐effects is critical to the development and implementation of interventions targeting parent‐infant interactions.

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