OBJECTIVETo determine whether interrupting prolonged sitting with brief bouts of lightintensity walking (LW) or simple resistance activities (SRA) improves postprandial cardiometabolic risk markers in adults with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODSIn a randomized crossover trial, 24 inactive overweight/obese adults with T2D (14 men 62 6 6 years old) underwent the following 8-h conditions on three separate days (with 6-14 days washout): uninterrupted sitting (control) (SIT), sitting plus 3-min bouts of LW (3.2 km · h 21 ) every 30 min, and sitting plus 3-min bouts of SRA (half-squats, calf raises, gluteal contractions, and knee raises) every 30 min. Standardized meals were consumed during each condition. Incremental areas under the curve (iAUCs) for glucose, insulin, C-peptide, and triglycerides were compared between conditions. RESULTS Compared with SIT CONCLUSIONSInterrupting prolonged sitting with brief bouts of LW or SRA attenuates acute postprandial glucose, insulin, C-peptide, and triglyceride responses in adults with T2D. With poor adherence to structured exercise, this approach is potentially beneficial and practical.Lifestyle interventions, including exercise, are the recommended front-line therapy in the management of type 2 diabetes (T2D), even after the commencement of hypoglycemic agents. Current guidelines stipulate that, in addition to 150 min/week of moderate-vigorous aerobic exercise, individuals with T2D should engage in resistance exercises at least 2-3 days/week (1). However, despite the known benefits, particularly for glucose metabolism and insulin sensitivity, meeting prescribed

No abstract

No abstract

anzctr.org.au ACTRN12613000576729 FUNDING: : This research was supported by a National Health and Medical Research Council (NHMRC) project grant (no. 1081734) and the Victorian Government Operational Infrastructure Support scheme.

Interrupting prolonged sitting with brief bouts of light-intensity walking or SRA reduces resting BP and plasma noradrenaline in adults with T2D, with SRA being more effective. Given the ubiquity of sedentary behaviors and poor adherence to structured exercise, this approach may have important implications for BP management in patients with T2D.