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Background The term transgender (TRANS) may be used for people whose gender identity differs from the one assigned at birth. A large part of this population segment faces social (lack of social support, discrimination, rejection, transphobia) and psychological (anxiety, depression) challenges. These factors, in turn, may negatively impact the quality of life (QoL) of these individuals. In this context, the aim of this study is to identify the factors associated with QoL of TRANS people. Methods Cross-sectional study with non-probability sample, conducted with TRANS and cisgender (CIS) adults living in a southeastern Brazilian state. The research questionnaire was accessed electronically and comprised sociodemographic, health, and QoL information. QoL was assessed through the Short-Form 6 dimensions (SF-6D) instrument. Multivariable linear regression analysis (forward method) was applied to determine the influence of independent variables on QoL (outcome variable). All variables that presented p < 0.10 in the bivariate analyses were included. The analyses were carried out in the Statistical Package for the Social Sciences (SPSS)® software, version 22.0, with a significance level of 5%. Results The sample included 65 TRANS individuals and 78 CIS individuals. The CIS group showed a predominance of people with higher education (p = 0.002) and higher income (p = 0.000) when compared with the TRANS sample. TRANS participants had worse QoL score (p = 0.014) and the same was observed when QoL was assessed by all dimensions (p ≤ 0.05). In addition, the place of residence and the report of recent prejudice remained associated with QoL even after adjusting for age, gender identity, occupation, and follow-up by a health professional (p < 0.05). Conclusion The TRANS population showed worse QoL when compared with the CIS population. Moreover, living in the state’s capital and having suffered episodes of prejudice were the factors remain statistically associated with the QoL among TRANS individuals.

Objective: To identify and map the available evidence on the implementation of public health policies directed at individuals with rare diseases, and to compare the implementation of these health policies between Brazil and other countries. Method: A scoping review guided by the PRISMA-ScR and JBI checklists. The search for articles was conducted in eight electronic databases, MEDLINE/Pubmed, Embase, Cochrane Library, Web of Science, Scopus, CINAHL, PsycINFO, and LILACS, using controlled descriptors, synonyms, and keywords combined with Boolean operators. All steps of this review were independently conducted by two researchers. The selected studies were classified by evidence hierarchy, and a generic quantitative tool was used for the assessment of the studies. Results: A total of 473 studies were identified, of which 13 which met all the inclusion criteria were selected and analyzed. Of these studies, 61.5% (n = 8) had final scores equal to or greater than 70%, i.e., they were classified by this tool as being well-reported. The comparative analysis of international rare diseases demonstrates that public authorities’ priorities and recommendations regarding this topic also permeate and apply to the Brazilian context. Conclusions: The evaluation and monitoring of public policies directed at rare disease patients are urgent and necessary to improve and implement such policies with less bureaucracy and more determination for this unique population that requires timely and high-quality care.

Background The term transgender (TRANS) may be used for people whose gender identity differs from the one assigned at birth. A large part of this population segment faces social (lack of social support, discrimination, rejection, transphobia) and psychological (anxiety, depression) challenges. These factors, in turn, may negatively impact the quality of life (QoL) of these individuals. The aim of this study is to identify factors that influence the quality of life of transgender people when compared with cisgender people (CIS). Methods Cross-sectional case-control study with non-probability sample, conducted with transgender and cisgender adults living in a southeastern Brazilian state. The research questionnaire was accessed electronically and comprised sociodemographic, health, and QoL information. QoL was assessed through the Short-Form 6 dimensions (SF-6D) instrument. Multivariate logistic regression was used to verify the participation of the independent variables in QoL. Odds ratio (OR) values and their respective confidence intervals (CI) were estimated. The analyses were carried out in the SPSS® software, version 22.0, with a significance level of 5%. Results The sample included 65 transgender and 78 cisgender individuals. The cisgender group showed a predominance of people with higher education (p = 0.002) and higher income (p = 0.000) when compared with the transgender group. Transgender participants had worse QoL score (p = 0.014) and the same was observed when QoL was assessed by dimension (p ≤ 0.05). In addition, having an income between 1 to 3 minimum wages (MW) reduced by 94.6% (OR = 0.054, CI = 0.004–0.707, p = 0.026) the chances of having better QoL, when compared with those with income higher than 3 MW. Living in the state’s capital reduced the chances of having better QoL by 96.2% (OR = 0.038, CI = 0.004–0.387, p = 0.006) when compared with those living in the countryside. Conclusion The transgender population showed worse QoL when compared with the cisgender population, with income and place of residence being the factors that influenced this indicator.

Background: The term transgender (TRANS) may be used for people whose gender identity differs from the one assigned at birth. A large part of this population segment faces social (lack of social support, discrimination, rejection, transphobia) and psychological (anxiety, depression) challenges. These factors, in turn, may negatively impact the quality of life (QoL) of these individuals. The aim of this study is to identify factors that influence the quality of life of transgender people when compared with cisgender people (CIS). Methods: Cross-sectional case-control study with non-probability sample, conducted with transgender and cisgender adults living in a southeastern Brazilian state. The research questionnaire was accessed electronically and comprised sociodemographic, health, and QoL information. QoL was assessed through the Short-Form 6 dimensions (SF-6D) instrument. Multivariate logistic regression was used to verify the participation of the independent variables in QoL. Odds ratio (OR) values and their respective confidence intervals (CI) were estimated. The analyses were carried out in the SPSS® software, version 22.0, with a significance level of 5%. Results: The sample included 65 transgender and 78 cisgender individuals. The cisgender group showed a predominance of people with higher education (p=0.002) and higher income (p=0.000) when compared with the transgender group. Transgender participants had worse QoL score (p=0.014) and the same was observed when QoL was assessed by dimension (p≤0.05). In addition, having an income between 1 to 3 minimum wages (MW) reduced by 94.6% (OR=0.054, CI=0.004 – 0.707, p=0.026) the chances of having better QoL, when compared with those with income higher than 3 MW. Living in the state’s capital reduced the chances of having better QoL by 96.2% (OR=0.038, CI=0.004 - 0.387, p=0.006) when compared with those living in the countryside. Conclusion: The transgender population showed worse QoL when compared with the cisgender population, with income and place of residence being the factors that influenced this indicator.