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CASE REPORTA 63-year-old female patient reported blisters on the face, neck, upper, and lower limbs, which exuded and evolved as hypochromias and sclerotic areas one year ago, with no therapeutic response to topical corticosteroid therapy and phototherapy (NBUVB). FIgure 1: A. Diffuse sclerotic hypochromic plaques on the face with alopecia. B. Detail of the dyschromic alterations, exulcerated lesion on the forehead, alopecia of the eyebrows and temporal margins Case for diagnosis. Sclerodermiform manifestations of porphyria cutanea tarda secondary to hepatitis C 481 An Bras Dermatol. 2019;94(4):479-81.Abstract: A 63-year-old black female patient with blisters and exulcerations on the face, neck, upper limbs, and subsequent evolution with hypochromic sclerotic areas and alopecia, is reported. Chronic hepatitis C and presence of high levels of porphyrins in urine were demonstrated. There was complete remission with the use of hydroxychloroquine, photoprotection, and treatment of hepatitis. Significant sclerodermoid involvement of the skin as a manifestation of porphyria cutanea tarda secondary to hepatitis C emphasizes the importance of diagnostic suspicion regarding skin manifestation in order to indicate the appropriate therapy, and to minimize the hepatic morbidity.