Objective: To determine the principal adverse effects of the tuberculosis treatment regimen recommended by the Brazilian Ministry of Health. Methods: A prospective descriptive study involving 79 tuberculosis patients treated at the Clinical Research Center of the Cassiano Antonio Moraes University Hospital, in the city of Vitória, Brazil, between 2003 and2006. The treatment regimen consisted of isoniazid, rifampicin, pyrazinamide and ethambutol for four months, followed by rifampicin and isoniazid for two months. During the treatment period, the patients were clinically evaluated every week and had a monthly medical visit. Results: The overall incidence of adverse effects was 83.54%. Articular/bone/muscle involvement was the most common, followed by skin involvement (24.94% and 22.09%, respectively). Adverse effects were more common in the second month of treatment (41.59%). Modification of the treatment regimen was unnecessary. One patient required concomitant medication to counter the adverse effects. The cure rate was 100%. Conclusions: The overall incidence of adverse effects related to the new treatment regimen recommended by the Brazilian Ministry of Health was high. However, none of those effects demanded a change in the regimen, which was effective in the patients evaluated.Keywords: Treatment outcome; Tuberculosis; Antitubercular agents; Adverse drug reaction reporting systems. The objective of this study was to determine the adverse effects of TB treatment with the RHZE regimen.

OBJECTIVE:To analyze the socioeconomic background and its relationship with spatial distribution of mortality due to violence. METHODS:Ecological study conducted to explore the space distribution of mortality due to violence in the city of Vitória, Southeastern Brazil, between 2000 and 2003, based on population and socioeconomic information. Mortality data were correlated with information on victim's place of residence, type of violence, gender, and skin color. Data were analyzed using space average, odds ratio, and cluster analysis. RESULTS:There were reported 828 deaths due to violence during the study period, accounting for 17% of all deaths in the city. Of these, 72% were homicides, 21.8% traffi c accidents, and 6% suicides. Violence victims were mostly young black males, living in poorer areas of the city. In contrast, as for suicide and traffi c accidents, the victims were older white females living in the wealthiest area of the city. CONCLUSIONS:The study showed that violence is a phenomenon occurring in all socioeconomic levels but black people at the lowest level are more likely to die from homicides while white well-off people are more likely to die from suicide and traffi c accidents.

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