Objective: The aim of this study was to evaluate how different parameters of short-term glycemic control would correlate with the perception of health-related quality of life (HRQoL) in patients with type 1 diabetes mellitus (T1D). Subjects and methods: A total of 50 T1D patients aged 18 to 50 years were evaluated with the questionnaires Problem Areas in Diabetes (PAID) scale and Diabetes Quality of Life (DQOL) measure after 30 days of self-monitoring of blood glucose (SMBG). Glycemic control was evaluated using glycated hemoglobin (HbA 1c ), mean glucose levels (MGL) in the prior month's data from SMBG (Accu-Check 360 o ), number of hypoglycemic episodes (< 70 mg/dL and < 50 mg/dL), and glycemic variability (GV).