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959 118) for women, with 68% of men and 44% of women below the estimated average requirement (EAR). The mean WOMAC pain score at 0, 12, 24, 36, and 48 months of follow up was 3.5 (SD 3.8), median score 2 (IQR 0; 6). After adjustment for age, gender, BMI, caloric intake, physical activity, smoking status, alcohol use, renal insufficiency, and the use of analgesics, subjects in the lowest gender-specific quintile of magnesium intake (Q1) had, on average, 1 point higher WOMAC knee pain scores than subjects in the highest quintile (Q5): Q1 β (95% CI) 1.00 (0.61-1.39), Q2 0.69 (0.32-1.06), Q3 0.25 (-0.12-0.62), Q4 0.25 (-0.14-0.64); p<0.0001. Conclusions: In a cohort of adults with prevalent radiographic knee osteoarthritis, magnesium intake overall was below recommended. Low magnesium intake at baseline was associated with increased pain in the affected knee over 48 months of follow up. These findings may be of growing importance as the average dietary magnesium intake for humans is declining.[3] References: