DHHC2 regulates dynamic palmitoylation of PSD95, a process that appears to be linked to changes in DHHC2 localization. The precise distribution and membrane dynamics of DHHC2 are not clear. We demonstrate that DHHC2 cycles between the plasma membrane and recycling endosomes (RE) and that this dynamic localization requires an intact C-terminal domain.

CDK12 aberrations have been reported as a biomarker of response to immunotherapy for metastatic castration-resistant prostate cancer (mCRPC). Herein, we characterize CDK12mutated mCRPC, presenting clinical, genomic, and tumor-infiltrating lymphocyte data.

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