The relationship between bacterial load and the microalga Chaetoceros muelleri was analyzed in a scale-up experiment. The microalga was grown during five days in a 0.4-L Erlenmeyer flask, 2-L Fernbach flask, 18-L Carboy and 400-L column, during which the cell density of C. muelleri, the abundance of heterotrophic bacteria, Vibrio spp., and total bacteria were determined. The highest specific growth rates (
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