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A series of D-glucosamine derivatives were synthesized (2-4) and evaluated for their antimicrobial activity. Some of the compounds investigated have shown significant antimicrobial activity against Gram-positive and Gram-negative bacterial strains as well as a few fungal strains. The results suggest that the presence of sugar moiety is necessary to biological activity.

In the centrosymmetric title complex, [Ni(C(7)H(7)N(4)O(3))(2)(C(5)H(5)N)(2)], the coordination geometry about the Ni(2+) ion is octahedral, with two deprotonated 1-methyl-3-(p-nitrophenyl)triazenide 1-oxide ions, viz. [O(2)NC(6)H(4)NNN(O)CH(3)](-), acting as bidentate ligands (four-electron donors). Two neutral pyridine (py) molecules complete the coordination sphere in positions trans to each other. The triazenide 1-oxide ligand is almost planar, the largest interplanar angle of 8.80 (12) degrees being between the phenyl ring of the p-nitrophenyl group and the plane defined by the N(3)O moiety. The Ni-N(triazenide), Ni-O and Ni-N(py) distances are 2.0794 (16), 2.0427 (13) and 2.1652 (18) A, respectively.

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Alcohols Q 0230Carbohydrates in Asymmetric Synthesis: Enantioselective Allylation of Aldehydes. -The process is investigated in the presence of Zn and Sn metal and the chirality is introduced by simple, inexpensive carbohydrates. The best results are presented in the scheme. -(APPELT*, H. R.; LIMBERGER, J. B.; WEBER, M.; RODRIGUES, O. E. D.; OLIVEIRA, J. S.; LUEDTKE, D. S.; BRAGA, A. L.; Tetrahedron Lett. 49 (2008) 33, 4956-4957; Cent. Univ. Franciscano, 97010 Santa Maria, Brazil; Eng.) -Lindner 47-081