Review question / Objective: The aim of this systematic review is to determine whether mechanical vibration increases alveolar bone density in animals models and their possible application during orthodontic treatment. In this sense, the focused question is: Is the increase in alveolar bone density by mechanical vibrations in animal models an alternative to improve bone quality during orthodontic treatment? Eligibility criteria: All published animal studies will be included. Animal studies where high or low frequency vibrations were be applied, Articles where density or osteogenesis were be measured and compared to a control group. All publications will be considered except for those where the full-text article will not available, or the authors’ affiliation or the place of publication will not be specified. Only articles published in English.