Hypertension or high blood pressure is a condition when there is an increase in blood pressure above the normal threshold (> 140/90 mmHg). The bioactive compounds in red ginger are dominated by the terpene group which has the ability to inhibit the action of Angiotensin Converting Enzyme (ACE-inhibitor). The interaction between ACE-inhibitory peptides can be predicted by the in silico method. The in silico method was used to predict the interaction and binding energy between bioactive compounds in red ginger ethanol extract (ligand) and ACE protein (receptor) which acts as an antihypertensive. The results of GC-MS obtained as many as 5 compounds (zingiberene, farnesene, ß -sesquiphellandrene, alpha-curcumene and trans-beta-farnesene. The docking results showed the lowest binding energy values ​​for each compound sequentially for ACE-trans beta farnesene, ACE-alpha curcumene, ACE-zingiberene, ACE-farnesene, ACE-beta sesquiphellandrene are -5.14 kcal/mol, -5.61 kcal/mol , -6.20 kcal/mol, -5.66 kcal/mol, and -6.55 kcal/mol. Based on these results, the lowest bond energy among the 5 compounds was -6.55 kcal/mol at ACE-beta sesquiphellandrene docking, so the red ginger ethanol extract can be proposed and tested further as a clinical candidate for antihypertensive drugs.

Fennel (Foeniculum vulgare Mill.) traditionally used by people as antifertility agent for female. Fennel leaves (Foeniculum vulgare Mill.) contain phytoestrogen that has role as antiestrogen or synthesized become antiestrogen. Coumarin is the kind phytoestrogen that can be antiestrogen to female reproductive organs such as ovary and utery. The aim of this research is to find out the influence of fennel leaves infuse (Foeniculum vulgare Mill.) on morphometric of ovary and utery in female rats (Rattus sp.) administered after parturition, to find out the effective dose  affecting the morphometric of ovary and utery and to find out the total coumarin consisted in fennel leaves (Foeniculum vulgare Mill.). This research was carried out by using CRD (Completely Randomized Design) consisted of 2 groups, those are control group (aquades) and treatment groups (doses of fennel leaves infuse 20 g/300 ml, 40 g/300 ml and 60 g/300 ml). The treatment was administered in the morning and afternoon for 15 days. After 15 days of treatment, the rats were sacrificed and dissected to measure the morphometry of reproductive organs (ovary and utery). The data obtained was analyzed by Analysis of Varian (ANOVA) and continued by LSD (Least Significance Different) test with significance of 5%. The measurement of coumarin level was performed by TLC (Thin Layer Chromatography) densitometry method. The result of this research showed that the administration of infused fennel leaves (Foeniculum vulgare Mill.) at dose of 20 g/300 ml, 40 g/300 ml and 60 g/300 ml significantly decreased ovarian weigh in female rats (Rattus sp.) after parturition (p<0,05), but not decreased the  length, width, thick of ovary, length and diameter of utery (p>0,05). No difference was observed between doses 20 g/300 ml, 40 g/300 ml and 60 g/300 ml, and it showed that the dose 20 g/300 ml of fennel leaves infuse was able to be used to decrease the weigth of ovary. Coumarin level observed in leaves is 0,09%, and it is higher than the coumarin content in fruit/seed.