Lansoprazole (LSP), a proton-pump inhibitor, belongs to class II drug. It is especially instable to heat, light, and acidic media, indicating that fabrication of a formulation stabilizing the drug is difficult. The addition of alkaline stabilizer is the most powerful method to protect the drug in solid formulations under detrimental environment. The purpose of the study was to characterize the designed multiple coating pellets of LSP containing an alkaline stabilizer (sodium carbonate) and assess the effect of the stabilizer on the physicochemical properties of the drug. The coated pellets were prepared by layer-layer film coating with a fluid-bed coater. In vitro release and acid-resistance studies were carried out in simulated gastric fluid and simulated intestinal fluid, respectively. Furthermore, the moisture-uptake test was performed to evaluate the influence of sodium carbonate on the drug stability. The results indicate that the drug exists in the amorphous state or small (nanometer size) particles without crystallization even after storage at 40°C/75% for 5 months. The addition of sodium carbonate to the pellet protects the drug from degradation in simulated gastric fluid in a dose-dependent manner. The moisture absorbed into the pellets has a detrimental effect on the drug stability. The extent of drug degradation is directly correlated with the content of moisture absorption. In conclusion, these results suggest that the presence of sodium carbonate influence the physicochemical properties of LSP, and the designed multiple coating pellets enhance the drug stability.

The Huguangyan Maar Lake is caused by a volcanic eruption. The original sediments at the bottom of the lake are natural yearbooks for the evolution of the earth’s climate and environment. A multi-beam sonar technique is used to scan the full coverage on the lake surface to get fine samples of echoes form the lake bottom. The information of the bathymetric data of the lake bottom is accurately described and the results of three-dimensional geomorphology imaging are given. The results show that the lake is divided into two parts, east and west, by a north-south underwater volcanic wall, and the maximum depth of water is over 22 meters. We apply a texture feature extraction method based on multi-scale fractal dimension to describe the characteristics of the sediments and roughness. Multi-scale fractal dimensions algorithm is used to extract waveform characteristics of depth samples in different directions. General distribution of sediment at the bottom of the lake is distinguished by the width of multi-scale fractal spectrum. The results obtained can be helpful for the estimation of the physical properties of sediments.

In this study, we try to find the possible emission source area of the grey haze through comparing the ground observation station weather data and remote sensing data for the grey haze process that Beijing-Tianjin-Hebei region experienced in November the 8-14, 2013 in which the degree of contamination range from severe to mild to severe. The result demonstrates that before the invasion of the cold air , the coverage of the grey haze reach its maximum where south central areas of Beijing-Tianjin-Hebei is more severer compared with the south central and peri-urban areas of Hebei province. For the greater intensity grey haze companied by the wind convergence in the surface boundary layer, the result of the MODIS satellite monitoring is consistent with the meteorological station observation. Whereas MODIS satellite monitoring method could make up the shortfall of the meteorological station for the mild grey haze in certain degree. After the cold air, haze primary development area is very obvious, and the starting position of haze in the role of diffusion by the wind is also here, based on this can lock the grey haze emission source area and make concrete origination by using the high resolution satellite. The precise positioning could provide the scientific basis for the pertinent management on pollution control for the local government and relevant authority.

Abstract. Surveying and mapping plays an important role in all aspects of economic development, national infrastructure construction and national defence construction. Especially in the overall and strategic level, most of them need to apply geospatial information. Geospatial information acquired through surveying and mapping technology has become an important strategic resource. Because space photography is faster, cheaper and unrestricted by regions and borders, countries around the world are scrambling to develop their own mapping satellites.In recent years, great breakthrough has been made in the field of on-board optical stereo mapping, many countries have launched satellites with surveying and mapping as the main function, and obtained image data from 1:50000 to 1:10000 scale. This paper describes a design of a stereo surveying and mapping camera system that can achieve 1:10000 scale maps.