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Thermoelectric power generation (TEG) technology with high figure of merit (ZT) has become the need of the modern world. TEG is a potent technology which can tackle most of the environmental issues such as global warming, change in climatic conditions over the globe, and for burning out of various resources of non-renewable energy like as petroleum deposits and gasolines. Although thermoelectric materials generally convert the heat energy from wastes to electricity according to the theories Seebeck and Peltier effects yet they have not been fully exploited to realize their potential. Researchers are focusing mainly on how to improve the current ZT value from 1 to 2 or even 3 by various approaches. However, a higher ZT value is found to be difficult due to complex thermoelectric properties of materials. Hence, there is a need for developing materials with high figure of merit. Recently, various nanotechnological approaches have been incorporated to improve the thermoelectric properties of materials. In this review paper, the authors have performed a thorough literature survey of various kinds of TEG technology.

Desmoid tumor, also known as aggressive fibromatosis, is well-characterized by abnormal Wnt/β-catenin signaling. Various therapeutic options, including imatinib, are available to treat desmoid tumor. However, molecular mechanism of why imatinib works remains unclear. Here, we describe potential roles of NOTCH2 and HES1 in clinical response to imatinib at genome and transcriptome levels. Materials and MethodsWe identified somatic mutations in coding and non-coding regions via whole genome sequencing. To validate the genetic interaction with expression level in desmoid-tumor condition, we utilized large-scale whole-genome sequencing and transcriptome datasets from the Pan-Cancer Analysis of Whole Genomes project. RNA-sequencing was performed using prospective and retrospective cohort samples to evaluate the expressional relevance with clinical response. ResultsAmong 20 patients, 4 (20%) had a partial response and 14 (66.7%) had stable disease, 11 of which continued for ≥1 year. With gene-wise functional analyses, we detected significant correlation between recurrent NOTCH2 noncoding mutations and clinical response to imatinib.Based on PCAWG data analyses, NOTCH2 mutations affect expression levels particularly in the presence of CTNNB1 missense mutations. By analyzing RNA-sequencing with additional desmoid tumor samples, we found that NOTCH2 expression was significantly correlated with HES1 expression. Interestingly, NOTCH2 had no statistical power to discriminate responders and non-responders. Instead, HES1 was differentially expressed with statistical significance between responders and non-responders A c c e p t e d A r t i c l e CANCER RESEARCH AND TREATMENT (CRT) 4

Oscillating Water Column (OWC) Wave Energy Converters (WEC) harness electricity through a Power-Take-Off (PTO) system from the induced-airflow by seawater oscillating inside a chamber. In general, an air chamber with a relatively small cross-sectional area is required compared to seawater chamber to obtain highvelocity air in the PTO system, and in order to simulate an accurate air flow rate in the air chamber, a threedimensional study is required. In this study, the dynamic response of OWC-WEC that is equipped with the channel of seawater exchange for the case of irregular waves has been numerically studied. The open source CFD software, OLAFLOW for the simulation of wave dynamics to the openFOAM and FOAM-extend communities, was used to simulate the interaction between the device and irregular waves. Based on the numerical simulation results, we discussed the fluctuation characteristics of three dimensional air flow in the air-chamber, wave deformation around the structure and the seawater flow inside the channel of seawater exchange. The numerical results the maximum air flow velocity in the air-chamber increases as the Ursell value of the significant wave increases, and the velocity of airflow flowing out from the inside of air chamber to the outside is greater than the speed of flowing into the air chamber from the outside.