Aim: Details such as diagnosis and outcome of patients transported by ambulance after telephone triage have not been fully revealed. The aim of this study was to reveal profile and outcome about patients transported by ambulance via telephone triage with dataset of telephone triage and population-based registry for emergency patients. Methods: This retrospective descriptive study with a one-year study period from January 1, 2016 to December 31, 2016 included patients selected from the telephone triage dataset who were transported by ambulance. Key parameters such as age, sex and date and time of ambulance dispatch were used to identify patient data from the ORION registry. We assessed the profile and outcome of the patients in a descriptive epidemiological analysis. Results: We included 4,293 patients in the selected datasets whose data were merged, of whom 2,998 patients (69.8%) returned home from the emergency department, 1,255 (29.2%) were hospitalized, 32 (0.7%) were transferred to other hospitals, and 8 (0.2%) died. The most common diagnosis in the emergency departments was "infectious gastroenteritis and colitis, unspecified [A09] (219, 5.1%)". Among the 1,255 hospitalized patients, 905 patients (72.1%) were discharged home, 254 patients (20.2%) remained hospitalized, 52 patients (4.1%) were transferred to other hospitals, 38 patients (3.0%) died, and 5 patients (0.5%) had missing data. The most common diagnosis was "cerebral infarction [I63.0-I63.9] (138, 11.0%)". Conclusion: This study revealed the profile and outcome of patients transported by ambulance after telephone triage.

Highlights 8.1% of COVID-19 patients were mechanically ventilated in the first outbreak in Osaka. The 30-day mortality rate of mechanically ventilated COVID-19 patients was 24.0%. Among these, 97% of patients were intubated within 14 days from clinical onset. Age ≥65 years and men were associated with a higher 30-day mortality rate. Among these, the median duration of viral RNA shedding from onset was 35 days.

Background We investigated factors associated with prolonged viral clearance of SARS-CoV-2 among non-severe adult patients in Osaka, Japan. A total of 706 laboratory-confirmed COVID-19 patients were enrolled in this longitudinal observational study between 29 January 2020 and 31 May 2020, across 62 hospitals and three non-hospital recuperation facilities. Methods Logistic regression analysis was performed to investigate the factors associated with prolonged (29 days: upper 25% in duration) viral clearance of SARS-CoV-2. Linear regression analysis was conducted to assess these factors 14 days after symptom onset. Results The median duration of viral clearance was 22 days from symptom onset. After adjustment for sex, age, symptoms, comorbidity, and location of recuperation, comorbidities were associated with prolonged duration: (OR, 1.77 [95% CI, 1.11–2.82]) for one, (OR, 2.47 [95% CI, 1.32–4.61]) for two or more comorbidities. Viral clearance 14 days after symptom onset was 3 days longer for one comorbidity and 4 days longer for two or more comorbidities compared to clearance when there was no comorbidity. Conclusion The presence of comorbidity was a robust factor associated with a longer duration of viral clearance, extending by 3 to 4 days compared to patients with no comorbidity.

Irradiation of 2-phenylisoflavones through a Pyrex filter gave 3 , 4-diphenylisocoumarins and phenanthro [9,10-c]isocoumarins; the former are precursors of the latter.

The coronavirus disease 2019 , caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), was identified in Wuhan, China in December 2019, after which a COVID-19 outbreak spread rapidly across the world. 1 On March 11, 2020, the World Health Organization (WHO) declared COVID-19 as a pandemic.A previous study has reported that pregnancy was associated with significantly increased chance of hospitalization, ICU admission, and the need for mechanical ventilation due to but