Recent development on distributed systems has shown that a variety of fairness constraints (some of which are only recently defined) play vital roles in designing self-stabilizing population protocols. Current practice of system analysis is, however, deficient under fairness. In this work, we present PAT, a toolkit for flexible and efficient system analysis under fairness. A unified algorithm is proposed to model check systems with a variety of fairness effectively in two different settings. Empirical evaluation shows that PAT complements existing model checkers in terms of fairness. We report that previously unknown bugs have been revealed using PAT against systems functioning under strong global fairness.

International audienceThis paper defines action-labelled quantitative transition systems as a general framework for combining qualitative and quantitative analysis. We define state-metrics as a natural extension of bisimulation from non-quantitative systems to quantitative ones. We then prove that any single state-metric corresponds to a bisimulation and that the greatest state-metric corresponds to bisimilarity. Furthermore, we provide two extended examples which show that our results apply to both probabilistic and weighted automata as special cases of action-labelled quantitative transition systems

Probabilistic Boolean network (PBN) modelling is a semi-quantitative approach widely used for the study of the topology and dynamic aspects of biological systems. The combined use of rule-based representation and probability makes PBN appealing for large-scale modelling of biological networks where degrees of uncertainty need to be considered.A considerable expansion of our knowledge in the field of theoretical research on PBN can be observed over the past few years, with a focus on network inference, network intervention and control. With respect to areas of applications, PBN is mainly used for the study of gene regulatory networks though with an increasing emergence in signal transduction, metabolic, and also physiological networks. At the same time, a number of computational tools, facilitating the modelling and analysis of PBNs, are continuously developed.A concise yet comprehensive review of the state-of-the-art on PBN modelling is offered in this article, including a comparative discussion on PBN versus similar models with respect to concepts and biomedical applications. Due to their many advantages, we consider PBN to stand as a suitable modelling framework for the description and analysis of complex biological systems, ranging from molecular to physiological levels.

We study the problem of computing a minimal subset of nodes of a given asynchronous Boolean network that need to be controlled to drive its dynamics from an initial steady state (or attractor) to a target steady state. Due to the phenomenon of state-space explosion, a simple global approach that performs computations on the entire network, may not scale well for large networks. We believe that efficient algorithms for such networks must exploit the structure of the networks together with their dynamics. Taking such an approach, we derive a decomposition-based solution to the minimal control problem which can be significantly faster than the existing approaches on large networks. We apply our solution to both real-life biological networks and randomly generated networks, demonstrating promising results.