In this paper purpose is investigate to effects of Hydroponic cultured Ginseng leaf Extract and Kidney function depression in Rheumatoid arthritis Rat model. Rheumatoid arthritis Rat model was used Rat Type Ⅱ Collagen + adjuvant and sequentially injected in tail 7days. Studying animal groups are as follows; GroupⅠ: Control group(n=5), groupⅡ: collagen injected Rat, GroupⅢ: collagen injected + Hydroponic cultured Ginseng leaf Extract 200mg/kg treated Rat, GroupⅣ: collagen injected + Hydroponic cultured Ginseng leaf Extract 100mg/kg treated Rat, GroupⅤ: collagen injected + Hydroponic cultured Ginseng leaf Extract 50mg/kg treated Rat, GroupⅥ: collagen injected + leflunomide 3.5mg/kg treated Rat. We analyzed hemotological variation and kidney function test by complete blood cell counter and biochemical examination. Also we experimented western blotting for investigate signal transduction protein expression differences in four groups. These findings suggested that oral administration of hydrophonic cultured Ginseng leaf extract can attenuated inflammatory and have a kideny function improvement effect.

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