Abstract-Time synchronization and localization are two important issues in wireless sensor networks. Although these two problems share many aspects in common, they are traditionally treated separately. In this paper, we present a unified framework to jointly solve time synchronization and localization problems at the same time. Furthermore, since the accuracy of synchronization and localization is very sensitive to the accuracy of anchor timings and locations, the joint time synchronization and localization problem with inaccurate anchors is also considered in this paper. For the case with accurate anchors, the joint maximum likelihood estimator and a more computationally efficient least squares (LS) estimator are proposed. When the anchor timings and locations are inaccurate, a generalized total least squares (GTLS) scheme is proposed. Cramér-Rao lower bounds (CRLBs) and the analytical mean square error (MSE) expressions of the LS based estimators are derived for both accurate and inaccurate anchor cases. Results show that the proposed joint estimators exhibit performances close to their respective CRLBs and outperform the separate time synchronization and localization approach. Furthermore, the derived analytical MSE expressions predict the performances of the proposed joint estimators very well.

The RER+ phenotype is frequently present in sporadic endometrial cancers and is expressed before and during clonal expansion. The underlying mutator mutations are probably heterogeneous, since the RER+ phenotypes were diverse. The absence of altered microsatellites in adjacent normal endometrium demonstrates that the expression of the RER+ phenotype is limited to neoplastic tissue. The bulk of the microsatellite alterations appeared to be acquired prior to clonal expansion, suggesting that expression of the underlying genomic instability contributes to, and is not a consequence of, transformation.

No abstract

No abstract

No abstract