Vitamins are essential for our daily life. Its shortage in our body can cause many disorders, decreased enzyme activities also affect the genetic factors. Vitamins should be supplied through the diet in the required amount. If it is not supplied properly, vitamin tablets will be prescribed. And also vitamin tablets are the co-medication for therapies such as anticancer, antitubercular, antiviral and anti-HIV treatments. Many newspapers reported that vitamin therapies are causing major health problems like nephro/urolithiasis, it can increase mortality rates in smokers by increasing the risk of lung cancer, it can cause abortion when it is taken during pregnancy. Thus here, we reviewed the adverse effects of vitamin therapy from various reported cases, books, instructions provided from various health organizations and also newspapers, and magazines. It can help health professionals to control and monitor the vitamin therapies and make awareness about the adverse effects and possible side effects of regular vitamin uptake to society.