Chalcones are useful intermediates in organic synthesis and exhibit a large number of different biological activities. Chalcones have been synthesized in high yields by Claisen-Schmidt condensation of substituted acetophenones with various aromatic aldehydes in the presence of 10 mol% of iodine at room temperature by grinding under solvent-free conditions. Résumé : Les chalcones sont des intermédiaires importants en synthèse organique et elles présentent un grand nombre d'activités biologiques diverses. On a réalisé la synthèse de chalcones avec des rendements élevés, par le biais d'une condensation de Claisen-Schmidt d'acétophénones substituées avec divers aldéhydes aromatiques, en présence de 10 moles % d'iode, à la température ambiante, par simple broyage dans des conditions sans solvant.

A simple and efficient procedure has been developed for the one-pot synthesis of 3,4-dihydroquinazolin-4-ones from anthranilic acids, ortho esters and amines using a catalytic amount of iodine under solvent-free conditions to afford the corresponding products in excellent yields. The direct use of commercially available catalyst, mild and solvent-free reaction conditions, short reaction time, easy workup and excellent yields are the advantages of the present protocol.

An efficient synthesis of symmetrical bisamides is described in which aldehydes are reacted with amides in the presence of 5 mol% of iodine to give the corresponding bisamides in high yields under neutral conditions.

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5-(Arylmethylidene)rhodanines have been synthesised in 88-95% yields by Knoevenagel condensation of various aromatic aldehydes with rhodanine in the presence of a catalytic amount of iodine at room temperature by grinding under solvent-free conditions.