Breast cancer is the most common type of invasive cancer among women and is the second leading cause of cancer-related death. The diagnosis of breast cancer is based on clinical examination combined with imaging and is confirmed by histopathological assessment. Imaging includes bilateral mammography and ultrasonography of the breast and regional lymph nodes (LNs). Axillary lymph node (ALN) metastasis is an important prognostic factor, and the diagnosis of ALN metastasis is essential for treatment planning, such as start of neoadjuvant chemotherapy or selection of a neoadjuvant chemotherapy agent [1-4]. Although ALN dissection is the standard method of staging in breast cancer, it is associated with postoperative morbidities, such as arm and shoulder pain, lymphedema, paresthesia, nerve injuries, and seroma [5,6]. Sentinel LN biopsy, a less-invasive procedure, is also being used for breast cancer staging, but its clinical application is limited to early-stage breast cancer with no clinical suspicion of ALN metastasis [7,8]. To overcome this limitation, imaging modal
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