were managed with the same regimen as pregnancy did not allow the systemic administration of other medication.To our knowledge, just one case of EF associated with pregnancy has been reported in the English literature. 4 The presence of EF in pregnancy poses a difficult therapeutic challenge, as virtually all of the agents used in the treatment of EF are contraindicated in pregnancy. References1 Ofuji S, Ogino A, Horio T, Oseko T, Uehara M. Eosinophilic pustular folliculitis. Acta Derm Venereol 1970; 50 : 195-203. 2 Tang MB, Tan E, Chua SH. Eosinophilic pustular folliculitis (Ofuji's disease) in Singapore: a review of 23 adult cases. Australas J Dermatol 2003; 44 : 44-47. 3 Sugita K, Kabashima K, Koga C, Tokura Y. Eosinophilic pustular folliculitis successfully treated with sequential therapy of interferon-γ and ciclosporin. Clin Exp Dermatol 2006; 31 : 709-710. 4 Kus S, Cardan I, Ince U, Uygur T. Eosinophilic pustular folliculitis (Ofuji's disease) exacerbated with pregnancies.Corporation, Japan) was used and we found white hairs in both patients. Figure 1(b,c) show white hairs within the white patch of the first patient. This finding indicates that not only epidermal melanocytes but also melanocytes in the hair follicles are destroyed in halo naevus. In addition, portable digital microscopy may be very useful for the detection of hair colour in halo naevus and vitiligo. Further observation in additional patients with halo naevi is necessary to confirm whether all halo naevi have leucotrichia.

planus. 2,3 The several varieties of apoptotic markers studied in the literature and the rarity of this lesion may explain in part the result's variation.Exploration of the cell proliferate degree exposed different results depending on the antibody used. In fact, in the epithelial basal layer, the proliferation rate varied between 36% with the anti-Ki67 antibody (inset image in Fig. 2a) and 70% with the antiproliferating cell nuclear antigen (anti-PCNA) antibody (Fig. 2b). Even suprabasal keratinocytes were positive to the anti-PCNA antibody. In the lymphocytic infiltrate, although Ki-67 was not detected (Fig. 2a), 30% of the lymphocytes expressed the PCNA (Fig. 2b). Because of its relatively long half-life, PCNA protein may be detected in cells that have left the cell cycle. 4 This may explain why we detected this protein in a more extensive way than the other proliferate marker, Ki-67. On the other hand, a statistical analysis have shown that when compared with normal mucosa, the expression of the PCNA is really significantly higher in the layers of the oral lichen planus 5 assessing our findings of a high proliferation ratio in the basal keratinocytes.Moreover, characterization of the infiltrating lymphocytes assessed that they are T cells (CD3 + ) and that 36% of them are of killer type (CD8 + ). Neither helper T lymphocytes (CD4 -) nor B lymphocytes (L26 -) were detected in the subepithelial infiltrate. Several studies have assessed that infiltrating cells in oral lichen planus are CD-4-positive and CD-8-positive T cells with a variable proportions. 6,7 Although we confirmed the T nature of the lymphocytes, we failed to detect the T helper cells (CD4 -) in the subepithelial infiltrate, that is in disagreement with previous studies on oral lichen planus. 8 These data may be explained by the fact that (i) these previous studies did not explore the very rare pigmentosus variety of lichen planus, or (ii) the biopsy studied here is of late stages of disease since a gradual accumulation of CD8 + cells is reported with disease progression. 9 Especially for the epithelial basal cell layer, the apoptosis process seems to affect more cells than do the proliferation one. These data are approved by a study that revealed an association between the Ki67 expression and the wild p53 expression in oral lichen planus 10 confirming the antitumoral role of p53 and explaining the low rate of malignant transformation observed in this disease.The results emphasize the originality of this case in two points: the relative low rate of apoptotic basal keratinocytes and the killer nature of the T cells infiltrating the lesion. Further reports are required confirming these findings to be particular to this rare lesion. EditorEpidermal cysts are the most common cutaneous cysts and can develop at any location of the body. While epidermal cysts Figure 2 Cells of the subepithelial infiltration express the proliferative marker Ki67 (a). Inset, few basal keratinocytes also show nuclear expression of Ki67. Several keratinocytes and infiltrati...