Tissue adhesives, which inherently serve as wound sealants or as hemostatic agents, can be further augmented to acquire crucial functions as scaffolds, thereby accelerating wound healing or elevating the efficacy of tissue regeneration. Herein, multifunctional adherent fibrous matrices, acting as self-adhesive scaffolds capable of cell/gene delivery, were devised by coaxially electrospinning poly(caprolactone) (PCL) and poly(vinylpyrrolidone) (PVP). Wrapping the building block PCL fibers with the adherent PVP layers formed film-like fibrous matrices that could rapidly adhere to wet biological surfaces, referred to as fibrous layered matrix (FiLM) adhesives. The inclusion of ionic salts (i.e., dopamine hydrochloride) in the sheath layers generated spontaneously multilayered fibrous adhesives, whose partial layers could be manually peeled off, termed derivative FiLM (d-FiLM). In the context of scaffolds/tissue adhesives, both FiLM and d-FiLM demonstrated almost identical characteristics (i.e., sticky, mechanical, and performances as cell/gene carriers). Importantly, the single FiLM-process can yield multiple sets of d-FiLM by investing the same processing time, materials, and labor required to form a single conventional adhesive fibrous mat, thereby highlighting the economic aspects of the process. The FiLM/d-FiLM offer highly impacting contributions to many biomedical applications, especially in fields that require urgent aids (e.g., endoscopic surgeries, implantation in wet environments, severe wounds).

A 65-year-old female underwent passenger traffic accident. She was putting a seat belt. She arrived at authors` emergency department via ground ambulance from other hospital. The patient complained of generalized abdominal pain, and her initial vital signs were blood pressure 101/51 mmHg, heart rate 85, respiratory rate 20, body temperature 36.8℃ and sPO2 97%. A seat-belt sign was seen from her anterior chest wall to lower right abdominal wall. We detected free air and fluid collection in her abdominal cavity of computed tomography scan which was performed at the previous hospital ( Fig. 3.). An emergency laparotomy was performed. About 1 L of fresh blood was collected in the abdominal cavity and a moderate amount of bowel spillage was detected. Multiple mesenteric lacerations were identified 190cm distal area from Treitz ligament and 5cm above from IC valve. Omental tearing was also identified. Cecal perforation was noted on the countermesenteric area. We decided one-stage operation. After adequate hemostasis, the omental and mesenteric tearing were repaired primarily. A partial cecaectomy was performed using stapler on the perforation of the cecum (Fig. 2.). The patient was discharged uneventfully. DISCUSSIONIn a blunt trauma, a cecal perforation is very rare. If the injury is identified without delay, cecal perforation could be managed with one-stage operation (1). Conflict of Interest StatementNo potential conflict of interest relevant to this article was reported.