No abstract

No abstract

Two patients of IgG4-related Mikulicz's disease (IgG4-RD) with progressive transformation of germinal centers (PTGC) arising in the submandibular glands are reported.The patients were a 58-year-old male and 39-year-old female who fulfilled the clinico-pathological diagnostic criteria for IgG4-RD, including ① markedly elevated serum IgG4 level, ② bilateral swelling of the submandibular and lacrimal glands, and ③ microscopic finding of an IgG4 + /IgG + plasma cell ratio of more than 40% in the germinal centers.Histopathologically, PTGCs are characterized by hyperplastic germinal centers composed of mantle zone lymphocytes and remnant of large germinal center cells with follicular lysis.Complete resection is the only treatment for PTGC. However, in patients with IgG4-RD, administration of a corticosteroid might be recommended and efficacious. Because of the possibility of recurrence or malignant transformation after surgery or other treatments, close follow-up is mandatory.To the best of our knowledge based on a thorough search of the literature, there is only one report other than ours of PTGC arising in the submandibular glands in a patient with IgG4-RD.

No abstract

During the past 23 years, from June 1989 to December 2012, our treatment paradigm for head and neck squamous cell carcinoma (HNSCC) had involved comprehensive use of chemotherapy and radiation therapy followed by surgery. Between 1989 and 2005, chemotherapy using fluorouracil and carboplatin had been administered via intravenous drip infusion as induction chemotherapy (ICT) , and more recently between 2006 and 2012 as concurrent chemoradiotherapy (CCRT) .In the present study, we examined the superiority of definitive CCRT (dCCRT) over the ICT followed by definitive radiotherapy (ICT-dRT) as to the impact on the treatment of HNSCC with the stage-categories of T2-T4a, retrospectively analyzing survival rates and laryngeal preservation rates at the 3-year point between the two groups. The number of patients assigned for this study was 76, all of whom were previously untreated, and of whom 51 suffered from laryngeal carcinoma and 25 from hypopharyngeal carcinoma : 21 with Stage Ⅱ, 25 with Stage Ⅲ, 23 with Stage ⅣA, 7 with Stage ⅣC. The three-year overall survival rate and cause-specific survival rate were 54.5％, 73.5％ in the ICT-dRT group and 69.2％, 80.5％ in the dCCRT group, respectively, both of which statistically had no difference. But the dC-CRT was found to contribute to obtaining a higher rate of laryngeal preservation than that of the ICT-dRT in T2 and T3 but not in T4a. In conclusion, dCCRT showed more significant efficacy for organ preservation on T2 and T3 HNSCC than ICT-dRT.