The 120-second surface application of ethyl acetate enhanced the shear bond strength between the repair resin and the denture base resin, although the bond durability was inferior to that of the conventional surface preparation.

No abstract

The objective of this study was to determine whether human immunodeficiency virus (HIV) protease inhibitors (saquinavir, ritonavir and nelfinavir) interact with other HIV protease inhibitors and/or HIV reverse transcriptase inhibitors (zidovudine, didanosine, lamivudine, zalcitabine and sanilvudine). We measured transport of nelfinavir, an HIV protease inhibitor which is known as a substrate for the multidrug resistance transporter P-glycoprotein (P-gp), in an epithelial monolayer model and Ki for P-gp of some drugs by a calcein flux assay. Transport in a basal to apical direction was 2-fold greater than apical to basal flux for nelfinavir, Ki for P-gp of a potent P-gp inhibitor cyclosporin A was 1.09 microM and those of ritonavir and nelfinavir were 111 microM and 28.6 microM, whereas all HIV reverse transcriptase inhibitors gave high K1 values. These data show that nelfinavir, which is a substrate for P-gp, inhibits a P-gp function as a drug efflux pump and that HIV reverse transcriptase inhibitors do not inhibit P-gp.

No abstract

Peroxo-bridged dinuclear cobalt(III) complexes, [{Co((D-Glc) 2 -tren)} 2 (µ-O 2 )]X 3 ‚5H 2 O (X ) Cl (2‚5H 2 O), Br (3‚5H 2 O)) and [{Co((Mal) , were prepared from CoX 2 ‚6H 2 O, tris(2-aminoethyl)-amine, and D-glucose (D-Glc) or maltose (R-D-glucopyranosyl-(1f4)-D-glucose; Mal), and were characterized by elemental analysis, UV-vis absorption, circular dichroism, 1 H and 13 C NMR spectroscopic techniques, and X-ray absorption and crystallographic analyses, where (aldose) 2 -tren is bis(N-aldosyl-2-aminoethyl)(2-aminoethyl)amine (aldose ) D-Glc, Mal). The structure of 2 and 4 were determined by X-ray crystallography to consist of two Co(III) ions bridged by a peroxo unit: 2‚4H 2 O‚CH 3 OH, orthorhombic, P2 1 2 1 2 1 (No. 19), a ) 19.384 (8) Å, b ) 23.468(5) Å, c ) 13.195(5) Å, V ) 6002(2) Å 3 , Z ) 4, D calcd ) 1.440 g cm -3 , T ) -99°C, R ) 0.078, R w ) 0.085 for 4961 reflections with I > 3σ(I); 4‚2.25H 2 O‚3.75CH 3 OH, monoclinic, P2 1 (No. 4), a ) 12.819(7) Å, b ) 49.168(18) Å, c ) 14.973(6) Å, ) 104.59(4)°, V ) 9130(7) Å 3 , Z ) 4, D calcd ) 1.459 gcm -3 , T ) -136°C, R ) 0.101 for 6837 reflections with I > 2σ(I). The hydrogen bondings between the sugar moieties deviates the Co-O-O-Co torsional angle from planarity to 100.4(6)°(2) and av 102(1)°(4). The electronic structures of the twisted Co 2 (µ-O) 2 core were discussed on the basis of extended Hückel MO calculations. The present discrete complexes have a tetravalent sugar domain around the dinuclear center and clearly demonstrated distinct sugarsugar interactions which could be a minimal model for so-called sugar clusters of glycoproteins on cell surfaces.