Abstract.[Purpose] The purpose of this study was to evaluate the benefit of 8-week home-based lower extremity strength training combined with whole body endurance training on peripheral muscle oxygenation in outpatients with chronic obstructive pulmonary disease (COPD).[Subjects] The 8 subjects were COPD patients (6 males, 2 females).[Methods] Using near infrared spectroscopy (NIRS), muscle oxygenation in the right vastus lateralis muscle at rest and during isometric contraction of 30% maximal voluntary contraction (MVC) were assessed before and after intervention. Also, MVC of the right quadriceps muscles, the muscle endurance time (TLIM), defined as the time from the onset of the isometric contraction of 30% MVC until termination of the test, and the distance covered in the incremental shuttle walking test (ISWD) were measured. [Results] Although there were improvements, no significant changes were seen in MVC, TLIM, and ISWD between before and after the 8-week intervention. Also, no changes were seen in NIRS parameters at rest and during muscle endurance exercise between before and after intervention.[Conclusion] Our results identify no statistically significant improvements in MVC and walking ability which could be acknowledged as an effect of pulmonary rehabilitation. Further investigation is needed to clarify the effect of pulmonary rehabilitation on muscle oxygenation.