-The smartphone has become a popular accessory in the pocket of many nursing students nowadays. They are widely accepted new devices much cheaper and more universal than PDAs. The use of smartphone applications would be the good supplement for nursing education. The smartphone provides a quick access to educational materials and guidelines during clinical, class and panel discussion. With downloadable applications, subscriptions, and reference materials, they can be used to engage students and reinforce learning anytime and anywhere. New nurses can review references online instructional videos prior to performing skills in their clinical practice. Furthermore, the rapid change of preferred treatments, drug dosages, postsurgical care, and preventive healthcare regimens requires knowledge update and lifelong learning for both nursing students and experienced nurses. This article will introduce the issues surrounding the use of smartphones in nursing education first, then discuss the related technologies in the design and development of smartphone applications.