Daun sirsak mengandung senyawa aktif flavonoid yang bermanfaat sebagai antioksidan. Daun sirsak akan lebih praktis untuk diaplikasikan sebagai kosmetik dalam bentuk lotion. Penelitian ini bertujuan melakukan formulasi dan uji aktivitas antioksidan lotion ekstrak etanol daun sirsak (Annona muricata L.) dengan metode DPPH. Ekstrak etanol daun sirsak diperoleh dengan metode maserasi dengan pelarut etanol 70% kemudian dibuat lotion dalam 3 formula FI (0,1%), FII (0,2%), FIII (0,3%). Lotion yang dibuat diuji karakteristik fisika meliputi uji organoleptis, homogenitas, tipe emulsi, pH, viskositas, daya lekat dan daya sebar. Serta uji aktivitas antioksidan menggunakan metode DPPH. Hasil pengujian organoleptis, homogenitas dan tipe emulsi dianalisis secara deskriptif. Sedangkan pengujian pH, daya lekat, daya sebar, viskositas dan aktivitas antioksidan dianalisis menggunakan regresi linier.Lotion ektrak etanol daun sirsak memiliki bentuk semikental, warna hijau muda, aroma khas lotion, pH 5,74 – 5,95 dan memiliki tipe emulsi M/A. Peningkatan variasi konsentrasi ekstrak etanol daun sirsak dalam lotion meningkatkan viskositas, daya lekat dan aktivitas antioksidan. Nilai IC50 terjadi peningkatan sebesar FI 101,826 ppm (antioksidan sedang), FII 87,530 ppm (antioksidan kuat), dan FIII 73,188 ppm (antioksidan kuat). Ditemukan hasil bahwa peningkatan konsentrasi ektrak etanol daun sirsak berpengaruh terhadap peningkatan aktivitas antioksidan dengan nilai signifikansi 0,001(p<0,05).Kata kunci: antioksidan, DPPH, daun sirsak, ekstrak etanol, lotion.

Patchouli plant (Pogostemon cablin Benth) is one of the essential oil-producing plants widely used in perfume, cosmetic, aromatherapy, antiseptic, antibacterial, and antifungal industries. The essential oil derived from patchouli leaves contains terpenoid compounds with antibacterial and antifungal activity. This study aims to determine the optimum formulation of patchouli oil spray gel as a wound antiseptic and to observe the irritation test of the samples. The spray gel formulations of patchouli oil were prepared in various concentrations i.e. 5%, 7.5%, and 10% (v/v), solved in aquadest with the addition of carbopol 940 as the gelating agent. The spray gels were tested to determine their physical characteristics, including the organoleptic test, homogeneity test, pH, adhesive dispersion test, viscosity test, and spray pattern test. The results showed that the patchouli oil spray gels were yellowish-white and had a distinctive odor and homogeneous texture with a pH 5. They all had adhesive dispersion, and the optimum viscosity of the spray gel was found at a 7.5% (v/v) concentration of patchouli oil. The irritation test was carried out using the patch test method with a score of erythema and edema. The results showed that all three formulas very mild irritation.

Neurodegenerative is often associated with aging. The aging process will affect the decrease in nerve cells, especially brain nerve cells. Ethyl acetate fraction of kemukus fruit ethanol extract (FEAEE) of kemukus fruit has been investigated as a memory enhancer with the Morris water maze (MWM) method. One of the shortcomings of the Morris water maze method is that it causes stress in test animals, thus affecting their memory. This study aims to determine the memory enhancing activity of FEAEE of kemukus fruit with the radial arm maze method This research is an experimental study with pre and posttest matched control group design using 25 male mice, Balb/c strains divided into 5 groups. Mice group 1 as a negative control group were given a 1% CMC Na solution of 17.5 mg/mL. Group mice 2 - 5 were given FEAEE of kemukus fruit with doses of 63, 126, 252, and 504 mg/kgBB, respectively. Test material is given orally for 21 days. Observations were made on the frequency of mice passing the platform correctly and incorrectly and calculating memory scores using the radial arm maze (RAM) method. Differences in memory scores were analyzed by the Mann Whitney test. The results showed that FEAEE steamed fruit has memory enhancing activity. Memory activity was indicated at doses of 63 and 252 mg / kg.Keywords: steamed fruit (Piper cubeba, L. f), ethyl acetate fraction, memory score, radial arm maze

Minyak Nilam (Patchouli oil) menunjukkan beberapa aktivitas farmakologi salah satunya yaitu sifat antibakteri. Kandungan minyak atsiri pada daun nilam mengandung patchouli alcohol sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi minyak nilam (Patchouli oil) dengan basis hidrokarbon dan basis absorpsi terhadap karakteristik fisik sediaan spray gel. Salep dibuat menggunakan metode peleburan dengan variasi konsentrasi minyak nilam F1 5%, FII 7,5%, dan FIII 10% sebagai zat aktif dengan basis yang berbeda. Salep dilakukan uji sifat fisik meliputi uji organoleptis, homogenitas, pH, viskositas, daya lekat dan daya sebar. Hasil uji organoleptis dan homogenitas dianalisis secara deskriptif, sedangkan hasil pH, viskositas, daya sebar, dan daya lekat dianalisis secara statistik dengan  regresi linier, untuk melihat pengaruh variasi konsentrasi minyak nilam (Patchouli oil)  dengan basis hidrokarbon dan basis absorpsi terhadap karakteristik fisik sediaan. Hasil penelitian menunjukkan bahwa salep minyak nilam dengan basis hidrokarbon memiliki warna putih tulang sedangkan pada basis absorpsi memiliki warna kuning muda. Salep dengan basis hidrokarbon dan absorpsi memiliki bau khas minyak nilam, bentuk semi padat dan tercampur secara homogen. Salep minyak nilam dengan basis hidrokarbon dan absorpsi berpengaruh terhadap karakteristik fisik sediaan salep. Kenaikan konsentrasi minyak nilam dapat menurunkan viskositas dan daya lekat, tetapi menaikkan daya sebar dan pH sediaan.

Patchouli plant (Pogostemon cablin Benth) produces essential oil-plants containing sesquiterpenes and patchouli alcohol compounds that function as anti-inflammatory. In addition, patchouli oil also contains terpenoid compounds that have antibacterial and antifungal activity. This study aims to determine the effect of wound healing in patchouli oil spray gel on rabbits. The spray gel formulation used in this study was to add the active substance of pure patchouli oil with concentrations of 5%, 7.5%, and 10%. The resulting spray gel formulation was tested on rabbit cuts with six treatments, namely positive control (bioplacenton), negative control (base), control without treatment, patchouli oil spray gel with concentrations of 5%, 7.5%, and 10%. The test was carried out for 14 days, giving the ointment two times a day (every 12 hours) with three replication. The analysis was carried out by calculating the average percentage of wound healing time and analyzed using the one-way ANOVA test. The results of the three formulations of patchouli oil spray gel showed that the preparation with a concentration of 10% had no significantly different results (P>0.05) compared to the positive control. Statistical results on the three spray gel formulation showed that there was a significant difference (p < 0.05) between the treatment groups. It can be said that the spray gel preparation at a concentration of 5% was significantly different from the preparation with a concentration of 10%. Where increasing the concentration of patchouli oil will accelerate the percentage of wound healing on the rabbit's back.