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The combined retaining structure has gradually received considerable attention in the slope engineering, due to its good reinforcement effects. However, most of the published research studies were focused on the seismic responses of the single-formal supporting structure only. The investigations of dynamic responses of the combined retaining structures are scarce, and the current seismic design is conducted mainly based on experiences. In this work, a series of large-scale shaking table tests were conducted to investigate the seismic responses of the combined retaining structures (i.e., prestressed anchor cables and double-row antisliding piles) and the reinforced slope under seismic excitations, including amplification effect of internal and surface acceleration of the reinforced slope, distribution and change of prestress of the anchor cable, dynamic response of soil pressure behind the antislide pile, and horizontal displacement of the reinforced slope surface. Test results show that, supported by the reinforcement of composite support system, the slope with the multilayer weak sliding surface can experience strong ground motion of 0.9 g. The load of the antisliding pile has reached 80% of its bearing capacity, and the load of the anchor cable has reached 75.0% of its bearing capacity. When the seismic intensity reaches 0.5 g, the slope surface has an obvious downward trend, which will make the corresponding soil pressure suddenly increase after the antislide pile. At the potential sliding zone, the axial force of the anchor cable will increase suddenly under the action of earthquake; after the earthquake, the initial prestress of the anchor cable will be lost, with the loss range of 17.0%∼23.0%. These test results would provide an important reference for the further study of the seismic performance of such composite support structure.

Ankylosing spondylitis (AS) is a chronic rheumatic disease that mainly affects the spinal joints (vertebrae). Spondylitis means inflammation of the spine, and ankylosing spondylitis means that bones tend to fuse. The AS causes the vertebrae to swell in the spine. Therefore, based on protein interaction network analysis, we conducted in-depth research on the molecular mechanism of key regulatory factors in the AS disease process. We carried out a differential analysis of the expression of miRNAs in disease samples and miRNAs in normal samples. Protein network interaction analysis is performed according to a group of target genes regulated by significant differentially expressed miRNAs and clustered into an interaction module. In addition, enrichment analysis of functions and pathways was performed on these modular genes. Based on the predictive analysis of multidimensional regulators, we identified a range of regulatory factors that have potential regulatory effects on AS, such as endogenous genes and transcription factors. We obtained 20 differentially expressed miRNAs and 7082 target genes and clustered into 11 modules. Enrichment results showed that these modular genes are mainly involved in the functions and pathways of protein polyubiquitination, neutrophil activation involved in immune response, and Wnt signaling pathway. We revealed ten transcription factors (MYC, NFKB1, and TP53). After network connectivity analysis, we obtained 12 internal drive genes (UBE2D1, CCNF, and NEDD4). These core genes are thought to be potential regulators of AS.MYC is also considered to be a core factor that inhibits SART3 phosphorylation and plays a vital role in the immunological pathogenesis of AS. The combination of the above analysis results can provide a new idea for biologists and medical scientists to study the immune pathogenesis of AS and can provide a valuable reference for subsequent treatment options.