Highly selective binding of basic amino acids, i.e. lysine, arginine, and histidine, by a negatively charged carboxylatopillar[5]arene (CP5A) is reported. And the complexation behavior of the CP5A host towards lysine metabolites including cadaverine (Cad), acetyl-l-lysine (AcLys) and trimethyl-l-lysine (TMLys) is also described.

We describe the one-pot synthesis, unique geometries and intriguing host–guest properties of a new class of supramolecular macrocycles – biphen[n]arenes (n = 3, 4).

OBJECTIVE: To develop an automatic system that grades the severity of facial signs through 'selfies' pictures taken by women of different ages and ethnics. METHODS: 1140 women from three ethnics (African-American, Asian, Caucasian), of different ages (18-80 years old), took 'selfies' by high resolution smartphones cameras under different conditions of lighting or facial expressions. A dedicated software, was developed, based on a Convolutional Neural Network (CNN) that integrates training data from referential Skin Aging Atlases. The latter allows to an immediate quantification of the severity of nine facial signs according to the ethnicity declared by the subject. These automatic grading were confronted to those assessed by 12 trained experts and dermatologists either on 'selfies' pictures or in live conditions on a smaller cohort of women. RESULTS: The system appears weakly influenced by lighting conditions or facial expressions (coefficients of variations ranging 10-13% for most signs) and leads to global agreements with experts' assessments, even showing a better reproducibility on some facial signs. CONCLUSION: This automatic scoring system, still in development, seems offering a new quantitative approach in the quantified description of facial signs, independent from human vision, in many applications, being individual, cosmetic oriented or dermatological with regard to the follow-up of medical anti-ageing corrective strategies. a des valeurs comparables de celles des experts, voire même de meilleure reproductibilit e dans certains cas. CONCLUSION: Ce syst eme de scorage automatique, encore en d eveloppement, semble offrir une nouvelle approche dans la description quantitative de signes du visage, ind ependante de l'oeil humain, dans de nombreuses applications, comme la personnalisation, a vis ee cosm etique ou dermatologique, dans le suivi de certaines strat egies m edicales de l'antivieillissement cutan e.

Multicomponent reactions are fundamentally different from two-component reactions, as multicomponent reactions can enable the efficient and step-economical construction of complex molecular scaffolds from simple precursors. Here, an unprecedented threecomponent direct C−H addition was achieved in the challenging meta-selective fashion. Fluoroalkyl halides and a wide range of alkenes, including vinylarenes, unactivated alkenes, and internal alkenes, were employed as the coupling partners of arenes in this strategy. The detailed mechanism presented is supported by kinetic isotope studies, radical clock experiments, and density functional theory calculations. Moreover, this strategy provided access to various fluoride-containing bioactive 1,1diarylalkanes and other challenging synthetically potential products.

ortho-Aminated vinylarene derivatives were obtained via a reaction of aryl iodides, N-benzoyloxyamines, and N-tosylhydrazones. This approach involves a palladium-catalyzed, norbornene-mediated ortho-amination/N-tosylhydrazone insertion reaction. In this transformation, one C-N bond and one C-C bond are formed and an amine group is introduced at the ortho position successfully.