Molecular crystals are complex systems exhibiting various crystal structures, and accurately modeling the crystal structures are essential for understanding their physical behaviors under high pressure. Here, we have performed an extensive structure searches of ternary carbon-nitrogen-oxygen (CNO) compound under high pressure by CALYPSO method and first principles calculations and successfully identified three polymeric CNO compounds with $ Pbam $,$ C2/m $ and $ I\bar{4}m2 $ symmetries under 100 GPa. Most interestingly, these structures are also dynamically stable at ambient pressure, and are potential high energy density materials (HEDMs). The energy densities of $ Pbam $, $ C2/m $ and $ I\bar{4}m2 $ phases of CNO are about 2.30 kJ/g, 1.37 kJ/g and 2.70 kJ/g, respectively, with the decompositions of graphitic carbon and molecular carbon dioxide and $\alpha$-N (molecular $ \rm N_2 $) at ambient pressure. The present results offer in-depth insights into the structural evolution and physical properties of CNO compounds under high pressures, which offer crucial insights for the design and synthesis of novel HEDMs.

No abstract

UAV remote sensing technology is used to analyze the characteristics of surface collapse and evaluate the degree of damage in the mining area, and the regularity of surface collapse in the mining area is studied. The distribution and variation characteristics of surface collapse pits and surface cracks and surface deformation characteristics are obtained from UAV images. Taking the area of collapse pits, the depth of collapse pits, the width of cracks, the drop of cracks, the density of cracks, surface subsidence and surface inclination as the evaluation factors, the fuzzy opinion centralized decision-making of the classical fuzzy comprehensive evaluation method is introduced into the combined weighting method, and the fuzzy comprehensive evaluation model based on AHP-CRITIC method is established. The results show that: (1) From August 2020 to June 2021, 125 surface cracks have increased; Three new collapse pits are generated, with a maximum area of about 323m2 and a maximum depth of about 21m; The surface deformation in the south of the mining area is obvious, forming a settlement funnel. (2) The severe damage degree of surface collapse is mainly distributed near the surface collapse pits, the moderate damage degree is mainly distributed in the central and southern part of the study area, and the mild and slight damage degree is mainly distributed in the periphery of the ore body.

Background Runt-related transcription factor 2 (RUNX2) plays a key role in the osteogenic differentiation. The study aimed to explore the effect of miR-153-3p on the osteogenic differentiation of human bone marrow derived mesenchymal stem cells (hBMSCs) and confirm its targeting effect on RUNX2. Results During the osteogenic differentiation of hBMSCs, the expression of miR-153-3p decreased at 1 d and reached a low peak at 3 d. After miR-153-3p mimic or inhibitor transfection, miRNA-153-3p expression level of hBMSCs dramatically increased or decreased, but the cell viability and proliferation ability were not notably changed. After miR-153-3p inhibitor transfection, the osteogenic differentiation was notably promoted which was confirmed with Alizarin red staining, alkaline phosphatase (ALP) activity and Western blot for RUNX2 and Collagen I, while miR-153-3p mimic transfection, the osteogenic differentiation was notably suppressed. The result of luciferase reporter gene experiment verified that RUNX2 was the target gene of miR-153-3p. Conclusion The results of this study indicate that the expression of miR-153-3p regulates the osteogenic differentiation of hBMSCs by targeting RUNX2.

This project proposes a physical form finding design method by generating concrete flexible formwork through digital algorithm, which aims to explore the potential formal correlation between real material as the medium of transmitting information in physical space and virtual data, so as to discuss the autonomy and intelligence of material under the support of digital design technology. The first part of this paper first discusses the current situation of the application and development of concrete materials in the field of digital construction in recent years, and then studies the adaptability of flexible formwork to the flowable characteristics of concrete materials; Then, the second part puts forward the moulding method of concrete physical shape finding through flexible and rigid composite formwork, and tries to explore the influence of formwork shape under the control of digital algorithm on this process; The third part of the paper records the process of concrete moulding experiment under this method to discuss the internal relationship between the physical form of concrete and combined formwork.