Depression and anxiety are common comorbidities in breast cancer patients. Whether depression and anxiety are associated with breast cancer progression or mortality is unclear. Herein, based on a systematic literature search, 17 eligible studies involving 282,203 breast cancer patients were included. The results showed that depression was associated with cancer recurrence [1.24 (1.07, 1.43)], all-cause mortality [1.30 (1.23, 1.36)], and cancer-specific mortality [1.29 (1.11, 1.49)]. However, anxiety was associated with recurrence [1.17 (1.02, 1.34)] and all-cause mortality [1.13 (1.07, 1.19)] but not with cancer-specific mortality [1.05 (0.82, 1.35)]. Comorbidity of depression and anxiety is associated with all-cause mortality [1.34 (1.24, 1.45)] and cancer-specific mortality [1.45 (1.11, 1.90)]. Subgroup analyses demonstrated that clinically diagnosed depression and anxiety, being female and of younger age (<60 years), and shorter follow-up duration (≤5 years) were related to a poorer prognosis. Our study highlights the critical role of depression/anxiety as an independent factor in predicting breast cancer recurrence and survival. Further research should focus on a favorable strategy that works best to improve outcomes among breast cancer patients with mental disorders.

Prostate cancer stem cells (PCSCs) play a critical role in prostate cancer progression and metastasis, which remains an obstacle for successful prostate cancer treatment. Tumor-associated macrophages (TAMs) are the most abundant immune cell population within the tumor microenvironment (TME). Systematic investigation of the interaction and network signaling between PCSCs and TAMs may help in searching for the critical target to suppress PCSCs and metastasis. Herein, we demonstrated that TAMs-secreted CCL5 could significantly promote the migration, invasion, epithelial-mesenchymal transition (EMT) of prostate cancer cells as well as the self-renewal of PCSCs in vitro. QPCR screening validated STAT3 as the most significant response gene in prostate cancer cells following CCL5 treatment. RNA-sequencing and mechanistic explorations further revealed that CCL5 could promote PCSCs self-renewal and prostate cancer metastasis via activating the β-catenin/STAT3 signaling. Notably, CCL5 knockdown in TAMs not only significantly suppressed prostate cancer xenografts growth and bone metastasis but also inhibited the self-renewal and tumorigenicity of PCSCs in vivo. Finally, clinical investigations and bioinformatic analysis suggested that high CCL5 expression was significantly correlated with high Gleason grade, poor prognosis, metastasis as well as increased PCSCs activity in prostate cancer patients. Taken together, TAMs/CCL5 could promote PCSCs self-renewal and prostate cancer metastasis via activating β-catenin/STAT3 signaling. This study provides a novel rationale for developing TAMs/CCL5 as a potential molecular target for PCSCs elimination and metastatic prostate cancer prevention.

The biofunctions and clinical implications of TAMs in cancer progression were summarized. • The current pharmaceutical targets in TAMs regulation were introduced and discussed.

BackgroundMyricetin and 1,3,4-thiadiazole derivatives were reported to exhibit favorable antiviral and antibacterial activities. Aiming to discover novel myricetin analogues with potent activities, a series of novel myricetin derivatives containing 1,3,4-thiadiazole moiety were synthesized, and their antibacterial and antiviral activities were evaluated.ResultBioassay results indicated that some target compounds exhibited potential antibacterial and antiviral activities. Among them, compounds 2, 3a, 3b, 3d, 3f, 3i, 3m and 3p exhibited excellent antibacterial activities against Xanthomonas oryzae pv. Oryzae (Xoo), with EC50 values of 42.7, 38.6, 20.8, 12.9, 22.7, 27.3, 18.3 and 29.4 μg/mL, respectively, which were better than that of thiadiazole-copper (94.9 μg/mL). Compounds 3b, 3d, 3e, 3f, 3i and 3o showed good antibacterial activities against Ralstonia solanacearum (Rs), with EC50 values of 37.9, 72.6, 43.6, 59.6, 60.6 and 39.6 μg/mL, respectively, which were superior to that of thiadiazole-copper (131.7 μg/mL). In addition, compounds 3d, 3f, 3i and 3m showed better curative activities against tobacco mosaic virus (TMV), with EC50 values of 152.8, 99.7, 127.1, and 167.3 μg/mL, respectively, which were better than that of ningnanmycin (211.1 μg/mL).ConclusionsA series of myricetin derivatives containing 1,3,4-thiadiazole scaffold were synthesized, and their antibacterial activities against Xoo and Rs and their antiviral activity against TMV were evaluated. Bioassays indicated that some target compounds exhibited potential antibacterial and antiviral activities. These results indicated this kind of myricetin analogues could be further studied as potential alternative templates in the search for novel antibacterial and antiviral agents.Electronic supplementary materialThe online version of this article (doi:10.1186/s13065-017-0336-7) contains supplementary material, which is available to authorized users.

This paper investigates the optimal transmit beamforming design of simultaneous wireless information and power transfer (SWIPT) in the multiuser multiple-input-single-output (MISO) downlink with specific absorption rate (SAR) constraints. We consider the power splitting technique for SWIPT, where each receiver divides the received signal into two parts: one for information decoding and the other for energy harvesting with a practical non-linear rectification model. The problem of interest is to maximize as much as possible the received signalto-interference-plus-noise ratio (SINR) and the energy harvested for all receivers, while satisfying the transmit power and the SAR constraints by optimizing the transmit beamforming at the transmitter and the power splitting ratios at different receivers. The optimal beamforming and power splitting solutions are obtained with the aid of semidefinite programming and bisection search. Low-complexity fixed beamforming and hybrid beamforming techniques are also studied. Furthermore, we study the effect of imperfect channel information and radiation matrices, and design robust beamforming to guarantee the worst-case performance. Simulation results demonstrate that our proposed algorithms can effectively deal with the radio exposure constraints and significantly outperform the conventional transmission scheme with power backoff.Index Terms-Wireless power transfer, SWIPT, specific absorption rate, MU MISO, beamforming, optimization. I. INTRODUCTIONSimultaneous wireless information and power transfer (SWIPT) is a new technology where information and energy flows co-exist, co-engineered to simultaneously provide communication connectivity and energy sustainability [1], [2]. It has been considered as a new promising solution to transmit information and energy to low power devices and to extend the battery lifetime of wireless networks, especially in wireless sensor networks and Internet of Things (IoT) applications. Compared to the traditional energy harvesting (EH) and green communication techniques, which collect energy from natural and man-made sources such as solar, wind or mechanical vibration, SWIPT can be fully controlled and optimized by harvesting energy from the radio-frequency (RF) signals. From the seminal work of Varshney [36], who introduced the concept of SWIPT and the fundamental trade-off between information and energy transfer (i.e., information-energy capacity region), substantial works appear in the literature that study SWIPT from different perspectives.