This review suggests that fosfomycin has significantly lower septic complications with an equivalent side effect profile in comparison with quinolone-based prophylaxis regimen for TRUSBP. There is an urgent need for appropriate antibiotic stewardship and it is paramount that studies with robust methodology are developed to establish the role of fosfomycin over existing antibiotic regimens for TRUSBP.

Background Physicians often face a dilemma to investigate alert and neurologically intact patients presenting with acute headache to emergency departments. Two Canadian prospective cohort studies evaluated high-risk clinical characteristics for subarachnoid haemorrhage in such patients and proposed clinical decision rules (Canadian rules 1, 2, 3, and Ottawa) for investigation of acute headache. We aimed to determine investigation rates for subarachnoid haemorrhage in a cohort of neurologically intact patients presenting with acute headache.