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The processes of aging and photoaging are associated with an increase in cellular oxidation. This may be in part due to a decline in the levels of the endogenous cellular antioxidant coenzyme Q10 (ubiquinone, CoQ10). Therefore, we have investigated whether topical application of CoQ10 has the beneficial effect of preventing photoaging. We were able to demonstrate that CoQ10 penetrated into the viable layers of the epidermis and reduce the level of oxidation measured by weak photon emission. Furthermore, a reduction in wrinkle depth following CoQ10 application was also shown. CoQ10 was determined to be effective against UVA mediated oxidative stress in human keratinocytes in terms of thiol depletion, activation of specific phosphotyrosine kinases and prevention of oxidative DNA damage. CoQ10 was also able to significantly suppress the expression of collagenase in human dermal fibroblasts following UVA irradiation. These results indicate that CoQ10 has the efficacy to prevent many of the detrimental effects of photoaging.

[1] Understanding the subduction processes along the Sunda Trench requires detailed constraints on the subducting lithosphere. We build a detailed tectonic map of the Wharton Basin based on reinterpretation of satellite-derived gravity anomalies and marine magnetic anomalies. The Wharton Basin is characterized by a fossil ridge, dated~36.5 Ma, offset by N-S fracture zones. Magnetic anomalies 18 to 34 (38-84 Ma) are identified on both flanks, although a large part of the basin has been subducted. We analyze the past plate kinematic evolution of the Wharton Basin by two-plate (India-Australia) and three-plate (India-Australia-Antarctica) reconstructions. Despite the diffuse plate boundaries within the Indo-Australian plate for the last 20 Ma, we obtain finite rotation parameters that we apply to reconstruct the subducted Wharton Basin and constrain the thickness, buoyancy, and rheology of the subducting plate. The lower subductability of younger lithosphere off Sumatra has important consequences on the morphology, with a shallower trench, forearc islands, and a significant inward deviation of the subduction system. This deviation decreases in the youngest area, where the Wharton fossil spreading center enters subduction: The discontinuous magmatic crust and serpentinized upper mantle, consequences of the slow spreading rates at which this area was formed, weaken the mechanical resistance to subduction and facilitate the restoration of the accretionary prism. Deeper effects include the possible creation of asthenospheric windows beneath the Andaman Sea, in relation to the long-offset fracture zones, and east of 105°E, as a result of subduction of the spreading center.Citation: Jacob, J., J. Dyment, and V. Yatheesh (2014), Revisiting the structure, age, and evolution of the Wharton Basin to better understand subduction under Indonesia,