The overview of allele distribution of important xenobiotic-metabolizing enzymes among a Russian population shows similarity to other Caucasians. The data will be useful for clinical pharmacokinetic investigations and for drug dosage recommendations in the Russian population.

Our results show that the interaction of genetic and lifestyle risk factors should be taken into account to elucidate the genetic influence of MDR1 variability on cancer susceptibility.

Abstract:The research considers and analyzes vibration isolation systems, whose design schemes are single degree of freedom systems, including nonlinear elements -displacement limiter and viscous damper. Presented are calculation formulas in closed form for linear systems in operational modes (for harmonic and impulse loads), algorithms and examples of calculation of linear and nonlinear systems in operational and transient modes. The calculation method and the above dependences are written using the transfer (TF) and impulse response functions (IRF) of linear dynamical systems and dependencies that determine the relationship between these functions. The effectiveness of 2 options of vibration isolation systems in transient modes is analyzed. There is significant reduction of load from the equipment to the supporting structures in the starting-stopping modes by the use of displacement limiter.