Aim: The demineralization of enamel adjacent to orthodontic brackets is a significant clinical problem. The purpose of this in-vitro study was to investigate the effect of various toothpastes to prevent demineralization around orthodontic brackets. Methods: The study included 42 extracted premolars which were divided into seven groups: Group I (Control group), Group II (Colgate Total),Group III (Dabur Red),Group IV (R.O.C.S), Group V (GC Tooth Mousse) (TM), Group VI (Apagard), Group VII (Toothmin). All groups were subjected to demineralization and remineralization cycles.The remineralizing agents were applied according to the group and subjected to pH cycling for 21 days which was followed by SEM-EDX analysis. Data obtained were statistically analyzed using SPSS IBM version 23 (ANOVA and post hoc-Tukey). Results: The Results of the study showed that the adequate efficacy of all the experimental groups, with the highest efficacy in preventing demineralization for Group V (CPP-ACP group) with Ca wt%- 46.89±1.98, P wt%-18.22±1.03 and Ca:P ratio 2.58±0.21and least efficacy for Group III (herbal group) Ca wt%-33.45±1.81, P wt%- 16.90±1.16 and Ca:P ratio 1.98±0.10). Conclusions : With the limitations of any in-vitro study, the following clinical conclusions can be drawn. The toothpaste containing CPP-ACP was efficient and effective both quantitatively and qualitatively in preventing demineralization around orthodontic brackets.