In a study founded on two random samples of 237 patients each from 1970--1977, 96% of the patients have had no complaints or they have felt much better after simple cholecystectomy. Retrospective analysis of 3822 patients with a standardized simple cholecystectomy with papilloplasty and without cholangiometry and cholangioscopy shows that only 4% have attacks of pain in the right side of the upper abdomen. In half of the cases an organic reason was found which had no connection with the bile duct.

In 577 determinations on 135 rats the age change in urinary excretion of histamine was investigated. After administering water, histamine concentration in 12-hour urine was estimated on the isolated atropinized guinea pig ileum. The results show that histamine concentration in the urine during growth (up to 44 wk.) and the amount of histamine excreted daily per gram body weight decreases with increasing age. Against this, the daily total histamine content of urine does not substantially change during the same period. At older ages (50–120 wk.) both the histamine concentration in urine and the total daily excretion drop substantially, the decrease in 2-year-old rats being almost to 1% of the values in young rats.

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