City tourism is one of the fastest growing travel segments worldwide [18] and the changing nature of city tourism becomes increasingly apparent in many cities. Facilitated by mobile access to information, tourists are increasingly seeking, finding and consuming 'local experiences' and the boundaries between tourists and residents become increasingly blurred. While the impact of the proliferation of information and communication technologies (ICTs) on the travel industry as well as on tourist behaviour and the travel experience has been widely acknowledged (Egger implications of this new type of tourism for future urban development have received little attention (Füller and Michel Int J Urban Regional 38(4): [1304][1305][1306][1307][1308][1309][1310][1311][1312][1313][1314][1315][1316][1317][1318] 2014). This paper aims to better understand the underlying causes of the changing nature of city tourism and how this change could impact the future development of cities. It is argued that in addition to the proliferation of ICTs, the phenomena of experiential travel and social acceleration have contributed to the rise in popularity of city tourism as well as to a change in tourist behaviour. Possible implications for the future development of cities resulting from this new type of tourism, as well as approaches to solving those challenges, are discussed. It becomes clear that an interdisciplinary approach will be required in order to fully understand the challenges posed by city tourism as well as to develop and implement strategies for a successful integration of tourism into future urban development.

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Between 1972 and 1976 15 patients with chronic renal failure of different aetiology and varying severity were observed who developed 23 hypercalcaemic phases during treatment with calcium-containing drugs. 12 instances of hypercalcaemia occurred during conservative treated during conservative treatment (serum creatinine 177-1061 mumol/l, equivalent to 20-120 mg/l) and 11 during chronic haemodialysis (serum creatinine 707-1061 mumol/l, equivalent to 80-120 mg/l). In 15 cases hypercalcaemia was caused by a hexacalciumhexasodium-heptacitratehydrate complex (Acetolyt), in 6 cases by the combined use of this drug with calcium ion-exchange resins on a calciumpolystyrolsulfonate base, and in two cases by the use of calcium tablets and calciumpolystyrolsulfonate, respectively. The daily doses of these drugs were in the usual therapeutic range in most cases. Deterioration of renal function was observed in two cases and coma in a further two cases. In 5 cases gastric ulcers were demonstrated. Three patients died. In no patient was there evidence of florid hyperparathyroidism. Treatment with calcium-containing drugs in patients with renal failure should only be carried out under regular control of calcium concentrations.

Seit der Erstbeschreibung des Ikterus infectiosus 1886 durch Adolf Weil (45) und dem Nachweis des Krankheitserregers im Jahre 1915 (21, 22, 42, 43) hat die Leptospirenund Leptospirosen-Forschung eine ständig fortschreitende Entwicklung genommen (27). Hierbei zeigte sich, daß eine hämorrhagische Diathese keineswegs zu den obligaten Symptomen der Weilschen Erkrankung gehört. Daher existieren nur wenige Mitteilungen über eine eingeheñdere Prüfung des plasmatischen Gerinnungsmechanismus bei Patienten mit hämorrhagischer Verlaufsform von Lepto- 11, 15, 18,32,34,35). Es soll deshalb über die Ergebnisse von Gerinnungs-und Fibrinolyse-Untersuchungen bei zwei Patienten während der immunisierenden Phase der Leptospirose mit hämorrhagischer Diathese berichtet werden. KasuistikFall 1: Der Patient K. J., geboren am 17. 5. 1926, von Beruf Schlachter, war bisher nie ernstlich krank. Acht Tage vor der Aufnahme in a Professor Dr. O. H. Arnold zum 60. Geburtstag.

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