Croton zambesicus Muell Arg. (Euphorbiaceae) syn C. amabilis Muell. Arg.; syn. C. gratissimus Burch is an ornamental tree grown in villages and towns of Nigeria. It is a Guineo-Congolese species widely spread in tropical Africa. The leaf decoction is used in Benin as antihypertensive and antimicrobial (urinary infections). [1] The Ibibios in Uruan area of Akwa Ibom State of Nigeria use the leaf traditionally as a remedy for malaria. Block et al reported that ent-trachyloban-3ß-ol, a trachylobane diterpene, isolated from dichloromethane extract of the leaves has cytotoxic activity on HeLa cells. [2] The alkaloidal fractions of the leaf have been reported to possess weak activity against Kelebsiella pneumoniae, Pseudomonas aeruginosa, Bacillis megaterium, Bacillus subtilis, Escherichia coli, Proteus mirabilis, Staphylococcus aureus, Aspergillus niger, Microsporum species and Penicillium species. [3] The alkaloidal fractions of the stem have also been reported to be active against all microorganisms mentioned above. [3] The essential oil found in the leaves contains Pcymene, linalool and beta-caryophyllene. [4] The constituents