Adherence to prescribed medication affects global clinical practice especially on chronic disease management resulting in adverse medical and economic burden. Reliable standard and practice in measuring adherence among patient is yet to be established clinically although aspects from user behavioural, clinical needs and technology-assisted devices design have been studied. Lack of real-time monitoring and inefficient method of medication consumption validation has been identified as the challenges in monitoring patient medication consumption’s pattern. The aim of this study is to design and deploy an IoT driven medication adherence manager. The proposed IoT architecture enabled by real time monitoring through a multi-sensor alert option in medicinal compartment to ensure adherence integrity. The reliability of the proposed device further enhanced with the mobile application and cloud storage and usage analytic support application. The medication adherence manager expected to digitize the medication consumption process thus improving the patient health and well-being at the same time reduce pharmaceutical wastage due to nonadherence.