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The published data for glycine12•13 illustrate this quite satisfactorily, and we have obtained similar data for ammonia and veronal. On the basis of these results the nature of the activation by these simple organic compounds appears to differ from that caused by proteins, but the parathyroid hormone, even in the high concentrations employed (as much as 75 units per ml. of digest solution) has no individual and characteristic effect of its own. Experimental A concentrate of "alkaline" phosphatase was prepared from beef kidney cortex by the method of Albers and Albers.14 The resulting solution was evaporated to dryness in the frozen state; such preparations are stable for months at 5The digest solutions were 0.025 M in borate buffer of (12) Bodansky,

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