Aim: to study opportunity of research the evacuation function of the stomach in young people by magnetic resonance imaging with a stress drinking test. Materials and methods: the study group included 20 young people (10 men and 10 women aged 23 ± 1,12 years). At the time of the study, each test person excluded organic and functional pathologies of the gastroduodenal zone. A method of magnetic resonance imaging of the stomach with a stress drinking test (still drinking water at room temperature with a volume of 1000.0 ml) was used. The examination lasted 30 minutes, scanning was carried out every 5 minutes, a total of 7 scans. Based on the obtained three-dimensional images of the DICOM format using the HorosMobile™ application (DICOM medical image viewer), the volumes of fluid in the stomach in dynamics were calculated for each test person in the study group according to the time intervals of the scans performed by the magnetic resonance imaging machine. Systematization and data processing were carried out a Microsoft Excel. A single graph was built for the study group in the Pages graphical editor (iWork productivity suite) based on the obtained data, reflecting the reference volumes of gastric contents relative to the time scale with possible deviations from the average. Results: regardless of the type of physique and shape of the stomach in the studied subjects, the evacuation of a larger volume of fluid (81,53-82,54%) occurred by the 15th minute of the study. Complete evacuation of gastric contents occurs between 25 and 30 minutes of the study. Conclusions: the results obtained by MRI studies of the stomach with a stress drinking test give an idea of the options for normal physiological evacuation of gastric contents in young people, in the absence of organic and functional pathology of the gastroduodenal zone.

Under the conditions of a chronic methionine diet (daily addition of amino acids to food (0.15 g/100 g) and water (1% solution)) during 2–12 weeks, the dynamics of liver tests, infl ammatory changes in the blood and blood lipids was monitored. It was found that a methionine diet (MD) leads, starting from 4 weeks of MD, to medium hyperhomocysteinemia, an increase in liver enzymes (AsAT – 1.73, AlAT – 1.5 times, p<0.05) and bilirubin (by 62.25%), which indicates the formed hepatopathy. Further (12 weeks of MD), the condition is aggravated by an abnormality of excretory liver function and the development of cholestasis (an increase in alkaline phosphatase by 1.65, bilirubin – by 3.31 times, p<0.05).

Aim: to study the structure, features of the findings and treatment of mixed infections in children at the present stage.Materials and methods. 85 case histories of children aged 5 months to 17 years and 10 months were examined, the final diagnosis of which included 2 or more infections on the basis of the children's infectious diseases department City Clinical Hospital № 7 of Izhevsk. Children with acute infectious pathology (acute intestinal infections, acute respiratory infections, herpes infections) are hospitalized in this hospital. Diagnostic methods: polymerase chain reaction, ELISA, bacteriological.Results. Mixed infections are equally common in both boys and girls, while there is a predominance of mixed infections in young children (up to 1 year and from 1 year to 3 years) 62.4%. The structure of infectious morbidity is consistently dominated by acute enteric infection – 83.5% cases and acute respiratory infections – 53.0% cases. The progression of SARS-CoV-2-associated and herpes-associated mixed infections is characterized by a pronounced polymorphism of clinical manifestations. The etiological factor for each nosology was deciphered only in 17.7%; in 43.5% of cases, only one etiological factor was verified in the laboratory; in 38.8% of cases, no etiological factor was confirmed in the laboratory.

The aim of  the  study  was  to  analyze  the  microvasculation  of  the  liver  in  administration  of  tautomeric forms of orotic acid for a methionine-induced liver pathology to assess the efficacy of the modified drugs and the potentialof their clinical use.Material and  methods. The  study  included  30  white  outbred  rats,  that  were  simulated  methionine induced hyperhomocysteinemia by the administration of methionine, dosage 0.15 g/100 g of the body we ight, via food  during  4  weeks.  Animals  with  hyperhomocysteinemia  were  divided  into  4  groups:  animals  of  group  1  received orotic acid (OA) in the initial form (oxo-tautomer), animals of group 2 received hydroxy–tautomer OA after mechanomodification for 1 hour, animals of group 3 received dihydroxy-tautomer OA after mechanomodification for 6 hours. Histological preparations of the liver were used to evaluate the area of hepatocytes; diameters and areas of the central vein, the interlobular vein and artery, the bile duct, and the Visotto coefficient were calculated.Results. Morphometric  data  of  the  hepatic  microvascular  bloodstream  with  simulated  hyperhomocysteinemia evidenced a general increase in the diameter and area of blood vessels, changes affected the system of blood inflow and outflow at the organ level. Administration of OA had a normalizing effect on the liver bloodflow, but the effects were different: the most pronounced effect was detected in administration of the hydroxy-form of the preparation, this can be explained by a modificationin the dispersion of the preparation (without changing the crystal lattice), an increase in the rate of dissolution in water and aqueous solutions, an increasein the number of functionally active groups in the heterocycle of the hydroxy-form of OA. Thus, the hydroxy-tautomer of orotic acid had the greatest efficacy relating to vasodilation of microvessels of the liver bloodstream in hyperhomocysteinemia; the fact suggesting feasibility of its further study in the clinical environment.